Journal article
Aldosterone in the brain
American journal of physiology. Renal physiology, Vol.297(3), pp.F559-576
09/2009
DOI: 10.1152/ajprenal.90399.2008
PMCID: PMC2739715
PMID: 19261742
Abstract
Pharmacological and physiological phenomena suggest that cells somewhere inside the central nervous system are responsive to aldosterone. Here, we present the fundamental physiological limitations for aldosterone action in the brain, including its limited blood-brain barrier penetration and its substantial competition from glucocorticoids. Recently, a small group of neurons with unusual sensitivity to circulating aldosterone were identified in the nucleus of the solitary tract. We review the discovery and characterization of these neurons, which express the enzyme 11beta-hydroxysteroid dehydrogenase type 2, and consider alternative proposals regarding sites and mechanisms for mineralocorticoid action within the brain.
Details
- Title: Subtitle
- Aldosterone in the brain
- Creators
- Joel C Geerling - Dept. of Anatomy and Neurobiology-Box 8108, Washington Univ. School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA. joel.geerling@gmail.comArthur D Loewy
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Renal physiology, Vol.297(3), pp.F559-576
- DOI
- 10.1152/ajprenal.90399.2008
- PMID
- 19261742
- PMCID
- PMC2739715
- NLM abbreviation
- Am J Physiol Renal Physiol
- ISSN
- 1931-857X
- eISSN
- 1522-1466
- Publisher
- United States
- Grant note
- R01 HL025449 / NHLBI NIH HHS HL-25449 / NHLBI NIH HHS
- Language
- English
- Date published
- 09/2009
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020606402771
Metrics
38 Record Views