Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment

Joel C Geerling; Arthur D Loewy

doi:10.1016/j.brainres.2006.07.091

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Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment

Journal article

Peer reviewed

Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment

Joel C Geerling and Arthur D Loewy

Brain research, Vol.1115(1), pp.54-64

10/18/2006

DOI: 10.1016/j.brainres.2006.07.091

PMID: 16935272

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Abstract

The nucleus of the solitary tract (NTS) contains a unique subpopulation of neurons that express the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2). These neurons are mineralocorticoid-sensitive and are activated in association with salt appetite during sodium deficiency. In the absence of sodium deficiency, the HSD2 neurons and sodium appetite are both stimulated by chronic mineralocorticoid administration. After 7 days of treatment with deoxycorticosterone (2 mg/day), an increased number of HSD2 neurons became immunoreactive for the neuronal activity marker c-Fos. When given access to concentrated saline (3% NaCl), deoxycorticosterone-treated rats drank eight times more than vehicle-treated rats. Saline ingestion increased neuronal activation within the medial subdivision of the NTS, but the number of c-Fos-immunoreactive HSD2 neurons was reduced. This finding suggests that the HSD2 neurons are inhibited by signals directly related to saline ingestion, and not simply by the alleviation of sodium deficiency, which does not occur during mineralocorticoid administration.

Immunohistochemistry

Sodium Chloride - pharmacology

Desoxycorticosterone - pharmacology

Male

Water-Electrolyte Balance - drug effects

Neural Inhibition - physiology

Sodium - deficiency

Aldosterone - metabolism

Up-Regulation - physiology

Solitary Nucleus - metabolism

Sodium Chloride - metabolism

Sodium, Dietary - metabolism

Water-Electrolyte Balance - physiology

Mineralocorticoids - metabolism

Proto-Oncogene Proteins c-fos - metabolism

Rats

Feedback - physiology

Mineralocorticoids - pharmacology

Solitary Nucleus - drug effects

Proto-Oncogene Proteins c-fos - drug effects

11-beta-Hydroxysteroid Dehydrogenase Type 2 - drug effects

Up-Regulation - drug effects

Feedback - drug effects

Animals

Sodium Chloride, Dietary - metabolism

11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism

Desoxycorticosterone - metabolism

Neural Inhibition - drug effects

Details

Title: Subtitle: Aldosterone-sensitive NTS neurons are inhibited by saline ingestion during chronic mineralocorticoid treatment
Creators: Joel C Geerling - Department of Anatomy and Neurobiology-Box 8108, Washington University School of Medicine, 660 S. Euclid Ave. St. Louis, MO 63110 USA
Arthur D Loewy
Resource Type: Journal article
Publication Details: Brain research, Vol.1115(1), pp.54-64
Publisher: Netherlands
DOI: 10.1016/j.brainres.2006.07.091
PMID: 16935272
ISSN: 0006-8993
eISSN: 1872-6240
Grant note: HL-25449 / NHLBI NIH HHS
Language: English
Date published: 10/18/2006
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984020621202771

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