Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite

Joel C Geerling; William C Engeland; Mitsuhiro Kawata; Arthur D Loewy

doi:10.1523/JNEUROSCI.3115-05.2006

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Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite

Journal article

Open access

Peer reviewed

Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite

Joel C Geerling, William C Engeland, Mitsuhiro Kawata and Arthur D Loewy

The Journal of neuroscience, Vol.26(2), pp.411-417

01/11/2006

DOI: 10.1523/JNEUROSCI.3115-05.2006

PMCID: PMC6674421

PMID: 16407537

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https://doi.org/10.1523/JNEUROSCI.3115-05.2006View

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Abstract

Sodium appetite can be enhanced by the adrenal steroid aldosterone via an unknown brain mechanism. A novel group of neurons in the nucleus tractus solitarius expresses the enzyme 11-beta-hydroxysteroid dehydrogenase type 2, which makes them selectively responsive to aldosterone. Their activation parallels sodium appetite in different paradigms of salt loss even in the absence of aldosterone. These unique aldosterone target neurons may represent a previously unrecognized central convergence point at which hormonal and neural signals can be integrated to drive sodium appetite.

Corticosterone - administration & dosage

Corticosterone - pharmacology

Proto-Oncogene Proteins c-fos - biosynthesis

Desoxycorticosterone - pharmacology

Male

Aldosterone - administration & dosage

Receptors, Mineralocorticoid - physiology

Neurons - classification

Sodium - deficiency

Solitary Nucleus - physiology

Hyponatremia - etiology

Genes, fos

Hyperaldosteronism - physiopathology

Hyponatremia - physiopathology

Neurons - physiology

Sodium, Dietary - administration & dosage

Appetite - physiology

Furosemide - toxicity

Receptors, Mineralocorticoid - analysis

Infusion Pumps, Implantable

Natriuresis - drug effects

Aldosterone - physiology

Rats

11-beta-Hydroxysteroid Dehydrogenase Type 2 - analysis

Aldosterone - pharmacology

Rats, Sprague-Dawley

Adrenalectomy

Diuresis - drug effects

Animals

Diet, Sodium-Restricted - adverse effects

Neurons - enzymology

11-beta-Hydroxysteroid Dehydrogenase Type 2 - physiology

Furosemide - pharmacology

Details

Title: Subtitle: Aldosterone target neurons in the nucleus tractus solitarius drive sodium appetite
Creators: Joel C Geerling - Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
William C Engeland
Mitsuhiro Kawata
Arthur D Loewy
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.26(2), pp.411-417
Publisher: United States
DOI: 10.1523/JNEUROSCI.3115-05.2006
PMID: 16407537
PMCID: PMC6674421
ISSN: 0270-6474
eISSN: 1529-2401
Grant note: R01 HL025449 / NHLBI NIH HHS R37 HL025449 / NHLBI NIH HHS HL-25449 / NHLBI NIH HHS
Language: English
Date published: 01/11/2006
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984020332102771

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