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All Roads Lead to ATF4
Journal article   Open access   Peer reviewed

All Roads Lead to ATF4

D.Thomas Rutkowski and Randal J Kaufman
Developmental Cell, Vol.4(4), pp.442-444
2003
DOI: 10.1016/S1534-5807(03)00100-X
PMID: 12689582
url
https://doi.org/10.1016/S1534-5807(03)00100-XView
Published (Version of record) Open Access

Abstract

Multiple intracellular stress pathways converge on a single event—phosphorylation of the translation initiation factor eIF2α and subsequent translational activation of the transcription factor ATF4. Exploring the consequences of this event has highlighted the ways in which stress is sensed and responded to via many distinct pathways.

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