All Things Complement

Joshua M Thurman; Carla M Nester

doi:10.2215/CJN.01710216

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Journal article

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All Things Complement

Joshua M Thurman and Carla M Nester

Clinical journal of the American Society of Nephrology, Vol.11(10), pp.1856-1866

10/07/2016

DOI: 10.2215/CJN.01710216

PMCID: PMC5053787

PMID: 27340286

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Abstract

The complement (C) cascade is an ancient system of proteins whose primary role is to initiate and modulate immune responses. During C activation, circulating proteins are cleaved and nascent cleavage fragments participate in a broad range of downstream innate and adaptive immune functions. Although the majority of these functions are either homeostatic or protective, a large body of experimental and clinical evidence also highlights a central role for the C system in the pathogenesis of many types of glomerular disease. From classic pathway activation in lupus nephritis to alternative pathway dysregulation in C3 glomerulopathy, our understanding of the spectrum of C involvement in kidney disease has expanded greatly in recent years. However, the characteristics that make the glomerulus so uniquely susceptible to C-mediated injury are not fully understood, and this remains an area of ongoing investigation. Several C inhibitors have been approved for clinical use, and additional C inhibitory drugs are in development. The use of these drugs in patients with kidney disease will expand our understanding of the benefits and limitations of C inhibition.

Biomarkers - metabolism

Animals

Complement Activation

Kidney Diseases - pathology

Humans

Kidney Diseases - drug therapy

Kidney Glomerulus - pathology

Complement System Proteins - metabolism

Disease Models, Animal

Kidney Diseases - metabolism

Details

Title: Subtitle: All Things Complement
Creators: Joshua M Thurman - Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado; and Joshua.Thurman@ucdenver.edu
Carla M Nester - Department of Internal Medicine, University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Clinical journal of the American Society of Nephrology, Vol.11(10), pp.1856-1866
DOI: 10.2215/CJN.01710216
PMID: 27340286
PMCID: PMC5053787
NLM abbreviation: Clin J Am Soc Nephrol
ISSN: 1555-9041
eISSN: 1555-905X
Language: English
Date published: 10/07/2016
Academic Unit: Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Internal Medicine
Record Identifier: 9984093501202771

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