Journal article
Allogeneic bone marrow transplantation vs chemotherapy for children with philadelphia chromosome-positive acute lymphoblastic leukemia
Bone marrow transplantation (Basingstoke), Vol.33(1), pp.39-45
2004
DOI: 10.1038/sj.bmt.1704319
PMID: 14566329
Abstract
Allogeneic bone marrow transplant (BMT) with an MRD in complete remission (CR)1 is the preferred treatment for children with Philadelphia-positive (Ph+) ALL. The role of MUD BMT in CR1 is still controversial. We compared the outcomes of two treatment strategies: BMT using an MRD or MUD vs chemotherapy in children with Ph+ ALL in CR1. In total, 21 children were treated from 1985 to 2001. In all, 10 received chemotherapy and 11 received allogeneic BMT: four MRD, seven MUD. In the MRD group, one relapsed 12 months after BMT and died; the remaining three are long-term event-free survivors (median follow-up, 6.1 years). In the MUD group four died; the remaining three are long-term event-free survivors (median follow-up, 7.2 years). The 4-year event-free survival (EFS) for the BMT group was 53±15%. In the chemotherapy group, seven relapsed after a median period of 12.5 months and three remain in continuous CR (median follow-up, 2.4 years). Four chemotherapy patients received CR2 transplants; all died. The 4-year EFS for the chemotherapy and MUD groups was 33±17 and 35.7±20%, respectively. This difference was not statistically significant. We continue to support treating children with Ph+ ALL with MRD BMT in CR1. The effectiveness of MUD BMT vs chemotherapy merits further study.
Details
- Title: Subtitle
- Allogeneic bone marrow transplantation vs chemotherapy for children with philadelphia chromosome-positive acute lymphoblastic leukemia
- Creators
- A Sharathkumar - University of TorontoE. F Saunders - University of TorontoY Dror - University of TorontoR Grant - University of TorontoM Greenberg - University of TorontoS Weitzman - University of TorontoH Chan - University of TorontoS Calderwood - City Of Hope National Medical CenterM. H Freedman - University of TorontoJ Doyle - University of Toronto
- Resource Type
- Journal article
- Publication Details
- Bone marrow transplantation (Basingstoke), Vol.33(1), pp.39-45
- Publisher
- Nature Publishing Group
- DOI
- 10.1038/sj.bmt.1704319
- PMID
- 14566329
- ISSN
- 0268-3369
- eISSN
- 1476-5365
- Language
- English
- Date published
- 2004
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984354148402771
Metrics
18 Record Views