Allogeneic peripheral blood stem cell transplant for myelodysplasia after chemotherapy for post-transplant lymphoma in a cardiac transplant recipient at 10 years

J LISTER; J. K SIMPSON; M. M DEMAGALHAES-SILVERMAN; W. B RYBKA; A. D DONNENBERG; D. J MYERS; E. D BALL

doi:10.1038/sj.bmt.1700758

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Allogeneic peripheral blood stem cell transplant for myelodysplasia after chemotherapy for post-transplant lymphoma in a cardiac transplant recipient at 10 years

Journal article

Peer reviewed

Allogeneic peripheral blood stem cell transplant for myelodysplasia after chemotherapy for post-transplant lymphoma in a cardiac transplant recipient at 10 years

J LISTER, J. K SIMPSON, M. M DEMAGALHAES-SILVERMAN, W. B RYBKA, A. D DONNENBERG, D. J MYERS and E. D BALL

Bone marrow transplantation (Basingstoke), Vol.19(9), pp.943-945

1997

DOI: 10.1038/sj.bmt.1700758

PMID: 9156271

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Abstract

A 32-year-old male received an allogeneic peripheral blood stem cell transplant (alloPBSCT) for myelodysplasia from his one HLA-A antigen mismatched brother. He is alive with trilineage engraftment and without active GVHD 200 days after transplant. In July 1986 he underwent orthotopic cardiac transplantation for viral cardiomyopathy and has received continuous immunosuppressive therapy. A post-transplant lymphoproliferative disorder with Hodgkin-like histopathology was diagnosed in August 1993 and was successfully treated with four cycles of MOPP chemotherapy. Due to persistent pancytopenia he underwent a bone marrow aspiration and biopsy in May 1996 which revealed monosomy 7 and morphologic changes compatible with myelodysplasia. This is the first report of a cardiac transplant recipient receiving an allogeneic hematopoietic stem cell transplant

Biological and medical sciences

Medical sciences

Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy

Bone marrow, stem cells transplantation. Graft versus host reaction

Transfusions. Complications. Transfusion reactions. Cell and gene therapy

Details

Title: Subtitle: Allogeneic peripheral blood stem cell transplant for myelodysplasia after chemotherapy for post-transplant lymphoma in a cardiac transplant recipient at 10 years
Creators: J LISTER - Division of Hematology/Bone Marrow Transplantation, Department of Medicine, University of Pittsburgh School of Medicine and the University of Pittshurgh Cancer Institute, Pittsburgh, PA, United States
J. K SIMPSON - Division of Hematology/Bone Marrow Transplantation, Department of Medicine, University of Pittsburgh School of Medicine and the University of Pittshurgh Cancer Institute, Pittsburgh, PA, United States
M. M DEMAGALHAES-SILVERMAN - Division of Hematology/Bone Marrow Transplantation, Department of Medicine, University of Pittsburgh School of Medicine and the University of Pittshurgh Cancer Institute, Pittsburgh, PA, United States
W. B RYBKA - Division of Hematology/Bone Marrow Transplantation, Department of Medicine, University of Pittsburgh School of Medicine and the University of Pittshurgh Cancer Institute, Pittsburgh, PA, United States
A. D DONNENBERG - Division of Hematology/Bone Marrow Transplantation, Department of Medicine, University of Pittsburgh School of Medicine and the University of Pittshurgh Cancer Institute, Pittsburgh, PA, United States
D. J MYERS - University of Pittsburgh
E. D BALL - Division of Hematology/Bone Marrow Transplantation, Department of Medicine, University of Pittsburgh School of Medicine and the University of Pittshurgh Cancer Institute, Pittsburgh, PA, United States
Resource Type: Journal article
Publication Details: Bone marrow transplantation (Basingstoke), Vol.19(9), pp.943-945
DOI: 10.1038/sj.bmt.1700758
PMID: 9156271
NLM abbreviation: Bone Marrow Transplant
ISSN: 0268-3369
eISSN: 1476-5365
Publisher: Nature Publishing Group
Language: English
Date published: 1997
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984094535602771

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