Journal article
Allogeneic stem cell transplantation and targeted therapy for FLT3/ITD+ acute myeloid leukemia: an update
Expert review of hematology, Vol.7(2), pp.301-315
04/2014
DOI: 10.1586/17474086.2014.857596
PMID: 24308526
Abstract
Survival of patients with acute myelogenous leukemia (AML), particularly in younger patients, has improved in recent years due to improved understanding of disease biology, post remission therapies and supportive care. AML, however, remains difficult to treat as many patients will still ultimately relapse and die of their disease. This is particularly true in AML patients with identified FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) molecular mutations, which typically confers a poor prognosis. The FLT3-ITD mutation occurs in about one-quarter of patients diagnosed with AML. Oftentimes, these patients are referred for early allogeneic hematopoietic stem cell transplantation (HSCT) in hopes of overcoming this poor prognostic factor. Several studies have demonstrated some benefit with HSCT in patients with FLT3-ITD mutation. However, recent data suggested that FLT3-ITD mutation remains a poor prognostic factor even after early HSCT; these patients remain at risk for early relapse after transplantation, emphasizing ongoing efforts to explore maintenance therapy with FLT3-ITD inhibitors in the post-transplant setting.
Details
- Title: Subtitle
- Allogeneic stem cell transplantation and targeted therapy for FLT3/ITD+ acute myeloid leukemia: an update
- Creators
- Bei Hu - 1 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USAPraveen Vikas - 2 University of Iowa Health Care, UI Medical Oncology and Hematology, McCreery Cancer Center, Ottumwa, IA, USAMohamad MohtyBipin N Savani - 6 Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Section of Hematology and Stem Cell Transplantation, Division of Hematology/ Oncology, 1301 Medical Center Drive, 3927 TVC Nashville, TN-37232, USA
- Resource Type
- Journal article
- Publication Details
- Expert review of hematology, Vol.7(2), pp.301-315
- Publisher
- Informa UK, Ltd
- DOI
- 10.1586/17474086.2014.857596
- PMID
- 24308526
- ISSN
- 1747-4086
- eISSN
- 1747-4094
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094535202771
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