Journal article
Allograft outcomes of treated children with kidney transplant who developed plasma cell-rich acute rejection (PCAR): A single center's experience
Pediatric transplantation, Vol.23(6), pp.e13500-n/a
09/01/2019
DOI: 10.1111/petr.13500
PMID: 31437388
Abstract
Introduction PCAR is a rare form of ACR that may compromise renal allografts. This review evaluates the outcomes of a protocol used to treat PCAR (Study group), and compares these outcomes with a matched cohort with ACR (Control group). Methods A retrospective analysis of 138 of pRTRs who underwent renal allograft biopsies between January 2008 and November 2016. Results Seven biopsies revealed in situ hybridization of EBER-negative PCAR (5%). Three Study group pRTRs lost their grafts within 3 months after rejection (43%). None of the Control group pRTRs lost their graft during this period. At the time of rejection, eGFR was different between the Control and Study groups (27.0 +/- 19.9 mL/min per m(2) vs 40.0 +/- 10.6 mL/min/1.73 m(2), respectively; P < 0.05). Among Study group pRTRs with functioning allografts (n = 4), treatment resulted in an increase in eGFR from nadir levels (27.0 +/- 19.9 vs 55.6 +/- 18.3 mL/min/1.73 m(2), P < 0.05). In the Study group, complications included neutropenia, BK and EBV viremia, and infusion-related hypotension and hypertension. (a) Graft loss in Study group while remaining high (43%) was lower than that reported in the published pediatric literature. (b) Our protocol was associated with improvement in eGFR in all surviving pRTRs within the Study group. (c) No life-threatening complications or malignancy were reported during the observation period.
Details
- Title: Subtitle
- Allograft outcomes of treated children with kidney transplant who developed plasma cell-rich acute rejection (PCAR): A single center's experience
- Creators
- Issa Alhamoud - The University of Texas Southwestern Medical CenterRong Huang - Children's Medical CenterChantale Lacelle - The University of Texas Southwestern Medical CenterDaniel Burguete - The University of Texas Southwestern Medical CenterAllen R. Hendricks - The University of Texas Southwestern Medical CenterJose R. Torrealba - The University of Texas Southwestern Medical CenterMouin G. Seikaly - The University of Texas Southwestern Medical Center
- Resource Type
- Journal article
- Publication Details
- Pediatric transplantation, Vol.23(6), pp.e13500-n/a
- Publisher
- Wiley
- DOI
- 10.1111/petr.13500
- PMID
- 31437388
- ISSN
- 1397-3142
- eISSN
- 1399-3046
- Number of pages
- 8
- Language
- English
- Date published
- 09/01/2019
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984354006202771
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