Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power

Kathryn F Hobbs; Jonah Propp; Nicholas R Vance; Andrew Kalenkiewicz; Katie R Witkin; M Ashley Spies

doi:10.1002/chem.202301621

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Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power

Journal article

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Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power

Kathryn F Hobbs, Jonah Propp, Nicholas R Vance, Andrew Kalenkiewicz, Katie R Witkin and M Ashley Spies

Chemistry : a European journal, Vol.29(40), e202301621

07/14/2023

DOI: 10.1002/chem.202301621

PMID: 37285583

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https://doi.org/10.1002/chem.202301621View

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Abstract

Invited for the cover of this issue is the group of Michael Ashley Spies at the University of Iowa. The image depicts how mapping allosteric structure–activity relationships reveals the nexus between the active site and the remote allosteric pocket. Read the full text of the article at 10.1002/chem.202300872.

Details

Title: Subtitle: Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power
Creators: Kathryn F Hobbs - University of Iowa
Jonah Propp - University of Iowa
Nicholas R Vance - University of Iowa
Andrew Kalenkiewicz - University of Iowa
Katie R Witkin - University of Iowa
M Ashley Spies - University of Iowa
Resource Type: Journal article
Publication Details: Chemistry : a European journal, Vol.29(40), e202301621
DOI: 10.1002/chem.202301621
PMID: 37285583
NLM abbreviation: Chemistry
eISSN: 1521-3765
Language: English
Electronic publication date: 06/07/2023
Date published: 07/14/2023
Academic Unit: Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Biochemistry and Molecular Biology; Medicinal and Natural Products Chemistry
Record Identifier: 9984433846302771

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