Alpha-adrenergic influences on neuronal responses to visceral afferent input in the nucleus tractus solitarius

P D Feldman; R B Felder

doi:10.1016/0028-3908(89)90121-4

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Alpha-adrenergic influences on neuronal responses to visceral afferent input in the nucleus tractus solitarius

Journal article

Peer reviewed

Alpha-adrenergic influences on neuronal responses to visceral afferent input in the nucleus tractus solitarius

P D Feldman and R B Felder

Neuropharmacology, Vol.28(10), pp.1081-1087

10/1989

DOI: 10.1016/0028-3908(89)90121-4

PMID: 2554181

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Abstract

Studies were made of the effects of the alpha 1-adrenoceptor agonist methoxamine on spontaneous and synaptically evoked activity in the solitary tract nucleus in isolated, perfused slices of the brain of the rat and those effects were compared to the effects of the alpha 2-agonist clonidine. Methoxamine had no effect on the spike activity of 7 out of 8 spontaneously firing neurones, with no response to electrical stimulation of the solitary tract. Among neurones that responded to tract stimulation, those which were otherwise silent (N = 38) showed a decrease of responsiveness to tract input during the infusion of methoxamine, whereas those with spontaneous activity (N = 10) showed mostly increases of both firing rate and responsiveness. The effects of activation of alpha 2-receptors on responsiveness to tract stimulation were the opposite of previously demonstrated effects of activation of alpha 2-receptors, and these opposing effects could be demonstrated in the same neurone. These results suggest that the transmission of visceral sensory information within the nucleus tractus solitarius may be controlled by opposing alpha 1- and alpha 2-receptor-mediated neural systems.

Electric Stimulation

Rats

Male

Electrodes, Implanted

Rats, Inbred Strains

Neurons, Afferent - physiology

Yohimbine - pharmacology

Evoked Potentials - drug effects

Medulla Oblongata - cytology

Animals

Methoxamine - pharmacology

Prazosin - pharmacology

Receptors, Adrenergic, alpha - physiology

Clonidine - pharmacology

In Vitro Techniques

Medulla Oblongata - physiology

Details

Title: Subtitle: Alpha-adrenergic influences on neuronal responses to visceral afferent input in the nucleus tractus solitarius
Creators: P D Feldman - Department of Internal Medicine and Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242
R B Felder
Resource Type: Journal article
Publication Details: Neuropharmacology, Vol.28(10), pp.1081-1087
Publisher: England
DOI: 10.1016/0028-3908(89)90121-4
PMID: 2554181
ISSN: 0028-3908
eISSN: 1873-7064
Grant note: HL07121 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS
Language: English
Date published: 10/1989
Academic Unit: Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984065376602771

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