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Alpha-gal syndrome (AGS) in a glaucoma suspect with narrow iridocorneal angles
Journal article   Open access   Peer reviewed

Alpha-gal syndrome (AGS) in a glaucoma suspect with narrow iridocorneal angles

Aminatta Z. Tejan-Kamara, Joan M. Murhammer and John H. Fingert
American journal of ophthalmology case reports, Vol.29, 101811
01/2023
DOI: 10.1016/j.ajoc.2023.101811
PMCID: PMC9926184
PMID: 36798447
url
https://doi.org/10.1016/j.ajoc.2023.101811View
Published (Version of record) Open Access

Abstract

Purpose Alpha-gal syndrome (AGS) is an allergy to non-primate mammalian carbohydrate (galactose-alpha-1,3-galactose) which may cause anaphylaxis. Allergic patients must avoid ophthalmic drugs containing animal-derived ingredients. Observations We report a 59-year-old non-Hispanic white woman who was referred for a glaucoma evaluation. She had been diagnosed with AGS after a tick bite in 2017. Ophthalmic exam revealed potentially occludable, narrow iridocorneal angles and laser iridotomy was recommended. Prior to performing the iridotomy, we investigated the ophthalmic medications required for the procedure to identify options that are free of animal-derived products and safe to use. Laser iridotomy was performed without complications or allergy to medications. Conclusions Ophthalmologists need to be aware of both the presence of AGS as well as the identity of ophthalmic medications that are safe to use in patients with this condition to avoid potentially lethal allergic responses.

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