Alphatorquevirus is the most prevalent virus identified in blood from a matched maternal-infant preterm cohort

Patrick Sloan; Cynthia Rodriguez; Bruce A Bedell; Jeffrey Murray; John Dagle; Kelli Ryckman; Lori Holtz

doi:10.1080/14767058.2020.1763298

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Journal article

Alphatorquevirus is the most prevalent virus identified in blood from a matched maternal-infant preterm cohort

Patrick Sloan, Cynthia Rodriguez, Bruce A Bedell, Jeffrey Murray, John Dagle, Kelli Ryckman and Lori Holtz

The journal of maternal-fetal & neonatal medicine, Vol.35(9), pp.1636-1642

2022

DOI: 10.1080/14767058.2020.1763298

PMCID: PMC8529647

PMID: 32401076

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https://www.ncbi.nlm.nih.gov/pmc/articles/8529647View

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Abstract

Objective: To determine the prevalence of virus in a previously uncharacterized matched maternal-infant preterm cohort and test if viral presence or viral load correlate with histologic chorioamnionitis, spontaneous preterm labor or pre-eclampsia. Study Design: Using qRT-PCR/qPCR we tested plasma or whole blood samples from 56 matched maternal and premature infant dyads for: adenovirus, anellovirus (alphatorquevirus and betatorquevirus), cytomegalovirus (CMV), Epstein-Barr virus (EBV), enterovirus, human herpesvirus 6 (HHV6), parechovirus, and parvovirus B19. Result: Viral detection was more common in maternal samples 29/56 (52%) than in cord blood from their infants (4/56 (7%)) (p ≤ .0001). No significant difference in viral load or viral prevalence was identified between pregnancies with and without histologic chorioamnionitis, spontaneous preterm labor or pre-eclampsia. Conclusion: Despite frequent detection of virus in maternal samples, virus was less frequently detected in the infants. Additionally, there was no association of presence or quantity of virus in maternal blood with histologic chorioamnionitis, spontaneous preterm labor or pre-eclampsia in this small, but well-defined cohort. Future studies are necessary to further characterize the role of virus in placental inflammatory states and pregnancy outcomes.

chorioamnionitis

cord blood

pre-eclampsia

preterm

Virus

Details

Title: Subtitle: Alphatorquevirus is the most prevalent virus identified in blood from a matched maternal-infant preterm cohort
Creators: Patrick Sloan - Department of Pediatrics Division of Newborn Medicine, Washington University School of Medicine
Cynthia Rodriguez - Department of Pediatrics, Washington University School of Medicine
Bruce A Bedell - Department of Pediatrics, University of Iowa
Jeffrey Murray - Department of Pediatrics, University of Iowa
John Dagle - Department of Pediatrics, University of Iowa
Kelli Ryckman - Department of Epidemiology, College of Public Health and Department of Pediatrics, Carver College of Medicine, University of Iowa
Lori Holtz - Department of Pediatrics, Washington University School of Medicine
Resource Type: Journal article
Publication Details: The journal of maternal-fetal & neonatal medicine, Vol.35(9), pp.1636-1642
DOI: 10.1080/14767058.2020.1763298
PMID: 32401076
PMCID: PMC8529647
NLM abbreviation: J Matern Fetal Neonatal Med
ISSN: 1476-7058
eISSN: 1476-4954
Publisher: Taylor & Francis
Grant note: BOC 388999 / March of Dimes 2017076 / Doris Duke Charitable Foundation
Language: English
Electronic publication date: 05/13/2020
Date published: 2022
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Biochemistry and Molecular Biology; Dental Research; Neonatology
Record Identifier: 9984214802502771

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