Alteration of four identified K+ currents in Drosophila muscle by mutations in eag

Yi Zhong; Chun-Fang Wu

doi:10.1126/science.2047864

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Alteration of four identified K+ currents in Drosophila muscle by mutations in eag

Journal article

Peer reviewed

Alteration of four identified K+ currents in Drosophila muscle by mutations in eag

Yi Zhong and Chun-Fang Wu

Science (American Association for the Advancement of Science), Vol.252(5012), pp.1562-1564

06/14/1991

DOI: 10.1126/science.2047864

PMID: 2047864

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Abstract

Voltage-clamp analysis of Drosophila larval muscle revealed that ether à go-go (eag) mutations affected all identified potassium currents, including those specifically eliminated by mutations in the Shaker or slowpoke gene. Together with DNA sequence analysis, the results suggest that the eag locus encodes a subunit common to different potassium channels. Thus, combinatorial assembly of polypeptides from different genes may contribute to potassium channel diversity.

Mutation

Membrane Potentials - drug effects

Calcium - pharmacology

Electric Stimulation

Muscles - physiology

Potassium Channels - physiology

Chromosome Mapping

Quinidine - pharmacology

Potassium Channels - drug effects

Drosophila - physiology

Potassium Channels - genetics

Animals

Larva

Kinetics

4-Aminopyridine - pharmacology

Drosophila - genetics

Details

Title: Subtitle: Alteration of four identified K+ currents in Drosophila muscle by mutations in eag
Creators: Yi Zhong - Department of Biology, University of Iowa, Iowa City 52242
Chun-Fang Wu
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.252(5012), pp.1562-1564
Publisher: United States
DOI: 10.1126/science.2047864
PMID: 2047864
ISSN: 0036-8075
eISSN: 1095-9203
Language: English
Date published: 06/14/1991
Academic Unit: Iowa Neuroscience Institute; Biology
Record Identifier: 9984070736202771

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