Journal article
Alteration of human accessory cell function by heat treatment: Role of IL-1 and class II MHC antigens
Human immunology, Vol.16(3), pp.234-246
1986
DOI: 10.1016/0198-8859(86)90051-0
PMID: 3487535
Abstract
Heat-treated monocytes (1 br, 45°C) cannot present soluble antigen or mitogen to purified autologous T cells. This is despite normal viability and normal expression of class II MHC antigens. They do not secrete IL-1 nor stimulate secretion of IL-2 by T cells. Addition of exogenous IL-1 or IL-2 does not, however, reconstitute the response to soluble antigen. Furthermore, even after overnight pulsing with antigen prior to heat treatment under circumstances in which the antigen is known to be appropriately processed, stimulation of T-cell proliferation still does not occur. Thus there appear to be at least two discrete lesions produced by heating: (1) failure of IL-1 production, per se, and (2) intrinsic failure to present previously processed antigen. It is also hypothesized that heat treatment may produce alterations in Ia molecules which specifically disallow transduction of the proliferation signal to T cells.
Details
- Title: Subtitle
- Alteration of human accessory cell function by heat treatment: Role of IL-1 and class II MHC antigens
- Creators
- Nancy E Goeken - From the Department of Medicine, Veterans Administration and University of Iowa Medical Centers, Iowa City, Iowa, USAZuhair K Ballas - From the Department of Medicine, Veterans Administration and University of Iowa Medical Centers, Iowa City, Iowa, USATina S Staggs - From the Department of Medicine, Veterans Administration and University of Iowa Medical Centers, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Human immunology, Vol.16(3), pp.234-246
- DOI
- 10.1016/0198-8859(86)90051-0
- PMID
- 3487535
- NLM abbreviation
- Hum Immunol
- ISSN
- 0198-8859
- eISSN
- 1879-1166
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1986
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094484302771
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