Journal article
Alteration of immune function by staphylococcal pyrogenic exotoxin type C: possible role in toxic-shock syndrome
The Journal of infectious diseases, Vol.147(3), pp.391-398
03/1983
DOI: 10.1093/infdis/147.3.391
PMID: 6833789
Abstract
Staphylococcal pyrogenic exotoxin type C (PE-C) suppressed synthesis of IgM antibodies to sheep erythrocytes by in vitro cultures of murine and rabbit splenocytes. Maximal suppression was observed on day 4 of culture and at PE-C doses of 0.1 and 0.01 microgram per 10(7) splenocytes. Endotoxin, added to cell cultures containing PE-C, caused further suppression of IgM synthesis. Endotoxin alone added to cultures was not immunosuppressive. Sublethal doses of PE-C plus endotoxin also suppressed complement-fixing antibody responses in rabbits to sheep erythrocytes; neither agent alone was suppressive. Further, the combination of PE-C and endotoxin blocked reticuloendothelial clearance of colloidal carbon by 50% during a 20-min period. PE-C enhanced the skin reactivity of rabbits previously sensitized to purified protein derivative. One-half of rabbits immunized with PE-C emulsified in adjuvant failed to make antibody to PE-C during a 112-day period. The animals that were nonresponsive to PE-C were able to make antibodies to sheep erythrocytes.
Details
- Title: Subtitle
- Alteration of immune function by staphylococcal pyrogenic exotoxin type C: possible role in toxic-shock syndrome
- Creators
- P M Schlievert
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.147(3), pp.391-398
- Publisher
- United States
- DOI
- 10.1093/infdis/147.3.391
- PMID
- 6833789
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Grant note
- AI18359 / NIAID NIH HHS
- Language
- English
- Date published
- 03/1983
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002378202771
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