Journal article
Alterations in Electroencephalography Theta as Candidate Biomarkers of Acute Cannabis Intoxication
Frontiers in neuroscience, Vol.15, pp.744762-744762
10/04/2021
DOI: 10.3389/fnins.2021.744762
PMCID: PMC8520987
PMID: 34671242
Abstract
The trend toward cannabis legalization in the United States over the past two decades has unsurprisingly been accompanied by an increase in the number of cannabis users and use patterns that potentially pose wider risks to the public like driving under the influence. As such, it is becoming increasingly important to develop methods to accurately quantify cannabis intoxication and its associated impairments on cognitive and motor function. Electroencephalography (EEG) offers a non-invasive method for quantitatively assessing neurophysiological biomarkers of intoxication and impairment with a high degree of temporal resolution. Twelve healthy, young recreational cannabis users completed a series of neurocognitive tasks with concurrent EEG acquisition using the ABM STAT X24 EEG headset in a within-subject counterbalanced design. The 1-h testbed consisted of resting state tasks and tests of attention and memory. Spectral densities were computed for resting state tasks, and event-related potentials (ERPs) were obtained for the attention and memory tasks. Theta band power (3–5 Hz) was decreased during cannabis intoxication compared to placebo during resting state tasks, as were average P400 and late positive potential (LPP) amplitudes during attention and memory tasks. Cannabis intoxication was also associated with elevated frontal coherence and diminished anterior–posterior coherence in the Theta frequency band. This work highlights the utility of EEG to identify and quantify neurophysiological biomarkers from recordings obtained during a short neurocognitive testbed as a method for profiling cannabis intoxication. These biomarkers may prove efficacious in distinguishing intoxicated from non-intoxicated individuals in lab and real-world settings.
Details
- Title: Subtitle
- Alterations in Electroencephalography Theta as Candidate Biomarkers of Acute Cannabis Intoxication
- Creators
- Christian D. Richard - Advanced Brain MonitoringJared R. Poole - Advanced Brain MonitoringMarissa McConnell - Advanced Brain MonitoringAmir H. Meghdadi - Advanced Brain MonitoringMarija Stevanovic-Karic - Advanced Brain MonitoringGreg Rupp - Advanced Brain MonitoringAbigail Fink - Advanced Brain MonitoringRose Schmitt - University of IowaTimothy L. Brown - University of IowaChris Berka - Advanced Brain Monitoring
- Resource Type
- Journal article
- Publication Details
- Frontiers in neuroscience, Vol.15, pp.744762-744762
- DOI
- 10.3389/fnins.2021.744762
- PMID
- 34671242
- PMCID
- PMC8520987
- NLM abbreviation
- Front Neurosci
- ISSN
- 1662-4548
- eISSN
- 1662-453X
- Publisher
- Frontiers Media S.A
- Grant note
- 75N95019C00052 / ;
- Language
- English
- Date published
- 10/04/2021
- Academic Unit
- Iowa Technology Institute; Pharmaceutical Sciences and Experimental Therapeutics; Driving Safety Research Institute; Industrial and Systems Engineering; Injury Prevention Research Center
- Record Identifier
- 9984627348302771
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