Alterations in White Matter Structure in Young Children With Type 1 Diabetes

Naama BARNEA-GORALY; Mira RAMAN; Larry A FOX; Michael TANSEY; Roy W BECK; Katrina J RUEDY; Craig KOLLMAN; PEIYAO CHENG; Allan L REISS; Paul MAZAIKA; Matthew MARZELLI; Tamara HERSHEY; Stuart A WEINZIMER; Tandy AYE; Bruce BUCKINGHAM; Nelly MAURAS; Neil H WHITE; Diabetes Research in Children Network (DirecNet)

doi:10.2337/dc13-1388

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Alterations in White Matter Structure in Young Children With Type 1 Diabetes

Journal article

Open access

Peer reviewed

Alterations in White Matter Structure in Young Children With Type 1 Diabetes

Naama BARNEA-GORALY, Mira RAMAN, Larry A FOX, Michael TANSEY, Roy W BECK, Katrina J RUEDY, Craig KOLLMAN, PEIYAO CHENG, Allan L REISS, Paul MAZAIKA, …

Diabetes care, Vol.37(2), pp.332-340

2014

DOI: 10.2337/dc13-1388

PMCID: PMC3898758

PMID: 24319123

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https://doi.org/10.2337/dc13-1388View

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Abstract

OBJECTIVE To investigate whether type 1 diabetes affects white matter (WM) structure in a large sample of young children. RESEARCH DESIGN AND METHODS Children (ages 4 to <10 years) with type 1 diabetes (n = 127) and age-matched nondiabetic control subjects (n = 67) had diffusion weighted magnetic resonance imaging scans in this multisite neuroimaging study. Participants with type 1 diabetes were assessed for HbA1c history and lifetime adverse events, and glucose levels were monitored using a continuous glucose monitor (CGM) device and standardized measures of cognition. RESULTS Between-group analysis showed that children with type 1 diabetes had significantly reduced axial diffusivity (AD) in widespread brain regions compared with control subjects. Within the type 1 diabetes group, earlier onset of diabetes was associated with increased radial diffusivity (RD) and longer duration was associated with reduced AD, reduced RD, and increased fractional anisotropy (FA). In addition, HbA1c values were significantly negatively associated with FA values and were positively associated with RD values in widespread brain regions. Significant associations of AD, RD, and FA were found for CGM measures of hyperglycemia and glucose variability but not for hypoglycemia. Finally, we observed a significant association between WM structure and cognitive ability in children with type 1 diabetes but not in control subjects. CONCLUSIONS These results suggest vulnerability of the developing brain in young children to effects of type 1 diabetes associated with chronic hyperglycemia and glucose variability.

General aspects

Diabetes. Impaired glucose tolerance

Biological and medical sciences

Endocrinopathies

Etiopathogenesis. Screening. Investigations. Target tissue resistance

Metabolic diseases

Medical sciences

Endocrine pancreas. Apud cells (diseases)

Details

Title: Subtitle: Alterations in White Matter Structure in Young Children With Type 1 Diabetes
Creators: Naama BARNEA-GORALY - Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford, CA, United States
Mira RAMAN - Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford, CA, United States
Larry A FOX - Pediatric Endocrinology, Nemours Children's Clinic, Jacksonville, FL, United States
Michael TANSEY - Pediatric Endocrinology, University of Iowa, Iowa City, IA, United States
Roy W BECK - Jaeb Center for Health Research, Tampa, FL, United States
Katrina J RUEDY - Jaeb Center for Health Research, Tampa, FL, United States
Craig KOLLMAN - Jaeb Center for Health Research, Tampa, FL, United States
PEIYAO CHENG - Jaeb Center for Health Research, Tampa, FL, United States
Allan L REISS - Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford, CA, United States
Paul MAZAIKA - Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford, CA, United States
Matthew MARZELLI - Department of Psychiatry and Behavioral Sciences, Center for Interdisciplinary Brain Sciences Research, Stanford, CA, United States
Tamara HERSHEY - Departments of Psychiatry, Neurology, and Radiology, Washington University in St. Louis, St. Louis, MO, United States
Stuart A WEINZIMER - Pediatric Endocrinology, Yale University, New Haven, CT, United States
Tandy AYE - Department of Pediatrics, Stanford University, Stanford, CA, United States
Bruce BUCKINGHAM - Department of Pediatrics, Stanford University, Stanford, CA, United States
Nelly MAURAS - Pediatric Endocrinology, Nemours Children's Clinic, Jacksonville, FL, United States
Neil H WHITE - Departments of Pediatrics and Medicine, Washington University in St. Louis, St. Louis, MO, United States
Diabetes Research in Children Network (DirecNet)
Resource Type: Journal article
Publication Details: Diabetes care, Vol.37(2), pp.332-340
DOI: 10.2337/dc13-1388
PMID: 24319123
PMCID: PMC3898758
NLM abbreviation: Diabetes Care
ISSN: 0149-5992
eISSN: 1935-5548
Publisher: American Diabetes Association
Language: English
Date published: 2014
Academic Unit: Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984093211702771

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