Alterations in cortical 40-Hz auditory steady-state response dynamics in children with mild-to-severe hearing loss are related to hearing aid use

Zhiying Shen; Wai Hon Lee; Jacob A Eastman; Michaela R Frenzel; Alex I Wiesman; Tony W Wilson; Elizabeth A Walker; Ryan W McCreery; Elizabeth Heinrichs-Graham

doi:10.1093/cercor/bhaf178

Back

Alterations in cortical 40-Hz auditory steady-state response dynamics in children with mild-to-severe hearing loss are related to hearing aid use

Journal article

Peer reviewed

Alterations in cortical 40-Hz auditory steady-state response dynamics in children with mild-to-severe hearing loss are related to hearing aid use

Zhiying Shen, Wai Hon Lee, Jacob A Eastman, Michaela R Frenzel, Alex I Wiesman, Tony W Wilson, Elizabeth A Walker, Ryan W McCreery and Elizabeth Heinrichs-Graham

Cerebral cortex (New York, N.Y. 1991), Vol.35(7), bhaf178

07/01/2025

DOI: 10.1093/cercor/bhaf178

PMCID: PMC12265889

PMID: 40668608

View Online

Abstract

Children who are hard-of-hearing (CHH) show greater variability in language and academic outcomes than children with normal hearing (CNH) throughout development, despite early detection and intervention. Nonetheless, our understanding of the neural mechanisms underlying sensory and cognitive processing in CHH remains incomplete. The 40-Hz cortical auditory steady-state response (ASSR) has been widely used as a marker of auditory system integrity and shown to relate to cognition. Thus, the current study sought to determine the impact of mild-to-severe hearing loss on cortical ASSR dynamics. Thirty-seven participants ages 7-15 years old heard a broadband click train stimulus presented at 40 Hz binaurally during magnetoencephalography (MEG). Peak sources in the bilateral primary auditory cortices were identified, and the power envelope of the 40 Hz ASSR was extracted as a function of time and submitted to linear mixed modeling. We found a significant three-way interaction, suggesting that CHH exhibit altered ASSR dynamics between hemispheres compared to CNH. Moreover, hearing aid use was significantly correlated with left hemisphere ASSR power in CHH. These data underscore the importance of consistent auditory access in CHH and provide preliminary evidence that neuroimaging may hold promise in determining the mechanisms underlying behavioral variability in this population.

Magnetoencephalography

Acoustic Stimulation

Adolescent

Auditory Cortex - physiopathology

Auditory Perception - physiology

Child

Evoked Potentials, Auditory - physiology

Female

Hearing Aids

Hearing Loss - physiopathology

Humans

Male

Details

Title: Subtitle: Alterations in cortical 40-Hz auditory steady-state response dynamics in children with mild-to-severe hearing loss are related to hearing aid use
Creators: Zhiying Shen - Boys Town
Wai Hon Lee - Boys Town
Jacob A Eastman - Boys Town
Michaela R Frenzel - Boys Town
Alex I Wiesman - Simon Fraser University
Tony W Wilson - Creighton University
Elizabeth A Walker - University of Iowa
Ryan W McCreery - Boys Town National Research Hospital
Elizabeth Heinrichs-Graham - Boys Town
Resource Type: Journal article
Publication Details: Cerebral cortex (New York, N.Y. 1991), Vol.35(7), bhaf178
DOI: 10.1093/cercor/bhaf178
PMID: 40668608
PMCID: PMC12265889
NLM abbreviation: Cereb Cortex
ISSN: 1460-2199
eISSN: 1460-2199
Publisher: OXFORD UNIV PRESS INC
Grant note: CRC-2023-00300 / Tier-2 Canada Research Chair program R01-DC013591 / NIH HHS P20-GM144641 / NIH HHS R21-DC020270 / NIH HHS
Language: English
Date published: 07/01/2025
Academic Unit: Communication Sciences and Disorders; Otolaryngology
Record Identifier: 9984848110802771

Metrics

8 Record Views

See more details