Alterations in the Fibrinolytic Cascade Post-transplant: Evidence of a Bimodal Expression Pattern

Raymond L Benza; Matthew A Cavender; Joseph Barchue; Jose A Tallaj; Robert C Bourge; James K Kirklin; Christopher S Coffey

doi:10.1016/j.healun.2007.02.003

Back

Alterations in the Fibrinolytic Cascade Post-transplant: Evidence of a Bimodal Expression Pattern

Journal article

Peer reviewed

Alterations in the Fibrinolytic Cascade Post-transplant: Evidence of a Bimodal Expression Pattern

Raymond L Benza, Matthew A Cavender, Joseph Barchue, Jose A Tallaj, Robert C Bourge, James K Kirklin and Christopher S Coffey

The Journal of heart and lung transplantation, Vol.26(5), pp.494-497

2007

DOI: 10.1016/j.healun.2007.02.003

PMCID: PMC1950728

PMID: 17449419

View Online

Abstract

Changes in the fibrinolytic system that occur after cardiac transplantation (CTx) and the factors that influence such changes have been poorly described, yet may be important in determining the varying morphologic features of transplant-related coronary artery disease (TxCAD). Baseline demographic as well as serial clinical information and plasma fibrinolytic levels were prospectively recorded pre-CTx and at multiple time-points post-CTx in 110 de novo cardiac transplant recipients. We noted a biphasic change in fibrinolytic activity over the first year of CTx with an early immediate decline in plasminogen activator inhibitor-1 (PAI-1) activity ( p > 0.001) matched with stable PAP (plasmin) activity corresponding to an “enhanced” fibrinolytic state early post-CTx. This was followed by a significant increase at 6 months ( p = 0.004) and 1 year ( p < 0.001) in PAI-1 activity concomitant with a significant decline in PAP after 3 months ( p = 0.005 at 3 months, p < 0.001 at 6 months, p < 0.001 at 1 year) corresponding to an “impaired” fibrinolytic state late post-CTx. The biphasic nature of the fibrinolytic system observed herein may account for the varying morphologic features of TxCAD.

Details

Title: Subtitle: Alterations in the Fibrinolytic Cascade Post-transplant: Evidence of a Bimodal Expression Pattern
Creators: Raymond L Benza - Department of Medicine, Division of Cardiovascular Disease, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
Matthew A Cavender - Department of Medicine, Division of Cardiovascular Disease, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
Joseph Barchue - Department of Medicine, Division of Cardiovascular Disease, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
Jose A Tallaj - Department of Medicine, Division of Cardiovascular Disease, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
Robert C Bourge - Department of Medicine, Division of Cardiovascular Disease, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
James K Kirklin - Department of Surgery, Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama
Christopher S Coffey - School of Public Health, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama
Resource Type: Journal article
Publication Details: The Journal of heart and lung transplantation, Vol.26(5), pp.494-497
DOI: 10.1016/j.healun.2007.02.003
PMID: 17449419
PMCID: PMC1950728
NLM abbreviation: J Heart Lung Transplant
ISSN: 1053-2498
eISSN: 1557-3117
Publisher: Elsevier Inc
Language: English
Date published: 2007
Academic Unit: Biostatistics
Record Identifier: 9984214836002771

Metrics

22 Record Views

6 Times Cited - Web of Science