Journal article
Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping
Bipolar disorders, Vol.20(4), pp.381-390
06/2018
DOI: 10.1111/bdi.12581
PMCID: PMC5995598
PMID: 29316081
Abstract
Objectives
Quantitative mapping of T1 relaxation in the rotating frame (T1ρ) is a magnetic resonance imaging technique sensitive to pH and other cellular and microstructural factors, and is a potentially valuable tool for identifying brain alterations in bipolar disorder. Recently, this technique identified differences in the cerebellum and cerebral white matter of euthymic patients vs healthy controls that were consistent with reduced pH in these regions, suggesting an underlying metabolic abnormality. The current study built upon this prior work to investigate brain T1ρ differences across euthymic, depressed, and manic mood states of bipolar disorder.
Methods
Forty participants with bipolar I disorder and 29 healthy control participants matched for age and gender were enrolled. Participants with bipolar disorder were imaged in one or more mood states, yielding 27, 12, and 13 imaging sessions in euthymic, depressed, and manic mood states, respectively. Three‐dimensional, whole‐brain anatomical images and T1ρ maps were acquired for all participants, enabling voxel‐wise evaluation of T1ρ differences between bipolar mood state and healthy control groups.
Results
All three mood state groups had increased T1ρ relaxation times in the cerebellum compared to the healthy control group. Additionally, the depressed and manic groups had reduced T1ρ relaxation times in and around the basal ganglia compared to the control and euthymic groups.
Conclusions
The study implicated the cerebellum and basal ganglia in the pathophysiology of bipolar disorder and its mood states, the roles of which are relatively unexplored. These findings motivate further investigation of the underlying cause of the abnormalities, and the potential role of altered metabolic activity in these regions.
Details
- Title: Subtitle
- Alterations of the cerebellum and basal ganglia in bipolar disorder mood states detected by quantitative T1ρ mapping
- Creators
- Casey P Johnson - University of IowaGary E Christensen - University of IowaJess G Fiedorowicz - University of IowaMerry Mani - University of IowaJoseph J Shaffer - University of IowaVincent A Magnotta - University of IowaJohn A Wemmie - Veterans Affairs Medical Center
- Resource Type
- Journal article
- Publication Details
- Bipolar disorders, Vol.20(4), pp.381-390
- DOI
- 10.1111/bdi.12581
- PMID
- 29316081
- PMCID
- PMC5995598
- NLM abbreviation
- Bipolar Disord
- ISSN
- 1398-5647
- eISSN
- 1399-5618
- Number of pages
- 10
- Grant note
- University of Iowa Institute for Clinical and Translational Science (U54TR001013) National Heart, Lung, and Blood Institute (P01HL014388; R01HL113863) National Institute on Drug Abuse (R01DA037216) National Institute of Mental Health (K23MH083695; R01MH085724; R01MH111578) Carver Foundation University of Iowa Foundation Brain and Behavior Research Foundation (NARSAD Independent Investigator Award; NARSAD Young Investigator Award) National Institutes of Health (U54TR001013)
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Molecular Physiology and Biophysics; Psychiatry; Epidemiology; Iowa Neuroscience Institute; Radiation Oncology; Radiation Research Laboratory; Neurosurgery; Internal Medicine
- Record Identifier
- 9984003949302771
Metrics
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