Journal article
Altered Cellular Pathways in the Blood of Patients With Guillain‐Barre Syndrome
Journal of the peripheral nervous system, Vol.30(1), e70012
03/2025
DOI: 10.1111/jns.70012
PMID: 40099626
Abstract
Background and Aims
Guillain-Barré syndrome (GBS) is a rare disorder, with a global incidence ranging from 1 to 2 individuals per 100,000 people/year. Infections and vaccines have been implicated as causes triggering GBS. The aim of the study was to identify host genes involved in the pathogenesis of GBS when Zika (ZIKV) and Chikungunya viruses (CHIKV) were introduced in Brazil.
Methods
A case–control study of GBS was performed when ZIKV and CHIKV were introduced into a naïve population. GBS was studied during both acute and postacute phases. RNA sequencing was conducted using whole blood.
Results
GBS typically manifested a week after rash and fever; acute inflammatory demyelinating polyradiculoneuropathy was more frequent. None of the GBS cases had a poor outcome. Serological assays for ZIKV and CHIKV revealed high titers of immunoglobulin G for both viruses in 9 out of 11 subjects. Metatranscriptomic analyses unveiled an increased abundance of reads attributed to Pseudomonas tolaasii and Toxoplasma gondii in the acute phase. Analysis of differentially expressed host genes during the acute phase revealed altered expression of genes associated with axogenesis, synapse assembly, and presynapse organization. Moreover, genes upregulated during acute GBS were primarily related to inflammation and the inflammasome pathways, including AIM2, NLR family genes and LRR-protein genes, and IL-10.
Interpretation
These findings suggest that inflammasome activation via AIM2 could play a role in tissue damage during GBS. Further investigation into the general activation of innate inflammatory responses is warranted to elucidate their potential contribution to the pathology of GBS.
Details
- Title: Subtitle
- Altered Cellular Pathways in the Blood of Patients With Guillain‐Barre Syndrome
- Creators
- Marília Fabiana de Oliveira Lima - University of Rio Grande and Rio Grande Community CollegeViviane Brito Nogueira - Universidade Federal do Rio Grande do NorteWendy Maury - University of IowaMary Edythe Wilson - University of IowaMário Emílio Teixeira Dourado Júnior - Hospital Universitário Onofre LopesDiego Gomes Teixeira - Universidade Federal do Rio Grande do NorteSelma Maria Bezerra Jerônimo - University of Rio Grande and Rio Grande Community College
- Resource Type
- Journal article
- Publication Details
- Journal of the peripheral nervous system, Vol.30(1), e70012
- Publisher
- WILEY
- DOI
- 10.1111/jns.70012
- PMID
- 40099626
- ISSN
- 1085-9489
- eISSN
- 1529-8027
- Grant note
- Instituto Nacional de Ciencia e Tecnologia de Doencas TropicaisConselho Nacional de Desenvolvimento Cientifico e Tecnologico
This work was supported by Instituto Nacional de Ciencia e Tecnologia de Doencas Tropicais, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico.
- Language
- English
- Date published
- 03/2025
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984801840302771
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