Journal article
Altered Neural Activity and Emotions Following Right Middle Cerebral Artery Stroke
Journal of stroke and cerebrovascular diseases, Vol.20(2), pp.94-104
2011
DOI: 10.1016/j.jstrokecerebrovasdis.2009.11.005
PMCID: PMC3014997
PMID: 20656512
Abstract
Stroke of the right MCA is common. Such strokes often have consequences for emotional experience, but these can be subtle. In such cases diagnosis is difficult because emotional awareness (limiting reporting of emotional changes) may be affected. The present study sought to clarify the mechanisms of altered emotion experience after right MCA stroke. It was predicted that after right MCA stroke the anterior cingulate cortex (ACC), a brain region concerned with emotional awareness, would show reduced neural activity. Brain activity during presentation of emotional stimuli was measured in 6 patients with stable stroke, and in 12 age- and sex-matched nonlesion comparisons using positron emission tomography and the [
15O]H
2O autoradiographic method. MCA stroke was associated with weaker pleasant experience and decreased activity ipsilaterally in the ACC. Other regions involved in emotional processing including thalamus, dorsal and medial prefrontal cortex showed reduced activity ipsilaterally. Dorsal and medial prefrontal cortex, association visual cortex and cerebellum showed reduced activity contralaterally. Experience from unpleasant stimuli was unaltered and was associated with decreased activity only in the left midbrain. Right MCA stroke may reduce experience of pleasant emotions by altering brain activity in limbic and paralimbic regions distant from the area of direct damage, in addition to changes due to direct tissue damage to insula and basal ganglia. The knowledge acquired in this study begins to explain the mechanisms underlying emotional changes following right MCA stroke. Recognizing these changes may improve diagnoses, management and rehabilitation of right MCA stroke victims.
Details
- Title: Subtitle
- Altered Neural Activity and Emotions Following Right Middle Cerebral Artery Stroke
- Creators
- Sergio Paradiso - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IowaBeth M Anderson - Olin Neuropsychiatry Research Center, Hartford, ConnecticutLaura L Boles Ponto - Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IowaDaniel Tranel - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IowaRobert G Robinson - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of stroke and cerebrovascular diseases, Vol.20(2), pp.94-104
- DOI
- 10.1016/j.jstrokecerebrovasdis.2009.11.005
- PMID
- 20656512
- PMCID
- PMC3014997
- NLM abbreviation
- J Stroke Cerebrovasc Dis
- ISSN
- 1052-3057
- eISSN
- 1532-8511
- Publisher
- Elsevier Inc
- Grant note
- MH52879 / National Institutes of Mental Health DA022549 / National Institute on Drug Abuse Edward J. Mallinckrodt Jr Foundation National Institutes of Health P50DC03189, RO1 DA10551, 1 R01 MH60990-01, and 7 R01 CA74959-04 / National Institutes of Health Dana Foundation NS19632 / National Institute of Neurological Disorders and Stroke
- Language
- English
- Date published
- 2011
- Academic Unit
- Neurology; Radiology; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984002592302771
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