Altered effective connectivity patterns of the default mode network in Alzheimer's disease: an fMRI study

Yufang Zhong; Liyu Huang; Suping Cai; Yun Zhang; Karen M von Deneen; Aifeng Ren; Junchan Ren; Alzheimer's Disease Neuroimaging Initiative

doi:10.1016/j.neulet.2014.06.043

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Altered effective connectivity patterns of the default mode network in Alzheimer's disease: an fMRI study

Journal article

Peer reviewed

Altered effective connectivity patterns of the default mode network in Alzheimer's disease: an fMRI study

Yufang Zhong, Liyu Huang, Suping Cai, Yun Zhang, Karen M von Deneen, Aifeng Ren, Junchan Ren and Alzheimer's Disease Neuroimaging Initiative

Neuroscience letters, Vol.578, pp.171-175

08/22/2014

DOI: 10.1016/j.neulet.2014.06.043

PMCID: PMC6293460

PMID: 24996191

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Abstract

The aim of this work is to investigate the differences of effective connectivity of the default mode network (DMN) in Alzheimer's disease (AD) patients and normal controls (NC). The technique of independent component analysis (ICA) was applied to identify DMN components and multivariate Granger causality analysis (mGCA) was used to explore an effective connectivity pattern. We found that: (i) connections in AD were decreased than those in NC, in terms of intensity and quantity. Posterior cingulated cortex (PCC) exhibited significant activity in NC as it connected with most of the other regions within the DMN. Besides, the PCC was the convergence center which only received interactions from other regions; (ii) right inferior temporal cortex (rITC) in the NC exhibited stronger interactions with other regions within the DMN compared with AD patients; and (iii) interactions between medial prefrontal cortex (MPFC) and bilateral inferior parietal cortex (IPC) in the NC were weaker than those in AD patients. These findings may implicate a brain dysfunction in AD patients and reveal more pathophysiological characteristics of AD.

Magnetic Resonance Imaging

Alzheimer Disease - physiopathology

Brain - physiopathology

Humans

Middle Aged

Aged, 80 and over

Brain Mapping

Female

Male

Aged

Nerve Net - physiopathology

Details

Title: Subtitle: Altered effective connectivity patterns of the default mode network in Alzheimer's disease: an fMRI study
Creators: Yufang Zhong - School of Life Science and Technology, Xidian University, Xi-an, Shaanxi 710071, China
Liyu Huang - School of Life Science and Technology, Xidian University, Xi-an, Shaanxi 710071, China. Electronic address: huangly@mail.xidian.edu.cn
Suping Cai - School of Life Science and Technology, Xidian University, Xi-an, Shaanxi 710071, China
Yun Zhang - School of Life Science and Technology, Xidian University, Xi-an, Shaanxi 710071, China
Karen M von Deneen - School of Life Science and Technology, Xidian University, Xi-an, Shaanxi 710071, China
Aifeng Ren - School of Life Science and Technology, Xidian University, Xi-an, Shaanxi 710071, China
Junchan Ren - School of Life Science and Technology, Xidian University, Xi-an, Shaanxi 710071, China
Alzheimer's Disease Neuroimaging Initiative
Contributors: Laura L Boles-Ponto (Contributor) - University of Iowa, Radiology
Resource Type: Journal article
Publication Details: Neuroscience letters, Vol.578, pp.171-175
DOI: 10.1016/j.neulet.2014.06.043
PMID: 24996191
PMCID: PMC6293460
NLM abbreviation: Neurosci Lett
ISSN: 0304-3940
eISSN: 1872-7972
Publisher: Ireland
Grant note: U01 AG024904 / NIA NIH HHS P30 AG013846 / NIA NIH HHS
Language: English
Date published: 08/22/2014
Academic Unit: Radiology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984051555702771

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