Altered mRNA expression after long-term soleus electrical stimulation training in humans with paralysis

Christopher M Adams; Manish Suneja; Shauna Dudley-Javoroski; Richard K Shields

doi:10.1002/mus.21831

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Altered mRNA expression after long-term soleus electrical stimulation training in humans with paralysis

Journal article

Peer reviewed

Altered mRNA expression after long-term soleus electrical stimulation training in humans with paralysis

Christopher M Adams, Manish Suneja, Shauna Dudley-Javoroski and Richard K Shields

Muscle & nerve, Vol.43(1), pp.65-75

01/2011

DOI: 10.1002/mus.21831

PMCID: PMC3058836

PMID: 21171097

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Abstract

In humans, spinal cord injury (SCI) induces deleterious changes in skeletal muscle that may be prevented or reversed by electrical stimulation muscle training. The molecular mechanisms underlying muscle stimulation training remain unknown. We studied two unique SCI subjects whose right soleus received >6 years of training (30 minutes/day, 5 days/week). Training preserved torque, fatigue index, contractile speed, and cross-sectional area in the trained leg, but not the untrained leg. Training decreased 10 mRNAs required for fast-twitch contractions and mRNA that encodes for myostatin, an autocrine/paracrine hormone that inhibits muscle growth. Conversely, training increased 69 mRNAs that mediate the slow-twitch, oxidative phenotype, including PGC-1α, a transcriptional coactivator that inhibits muscle atrophy. When we discontinued right soleus training, training-induced effects diminished slowly, with some persisting for >6 months. Training of paralyzed muscle induces localized and long-lasting changes in skeletal muscle mRNA expression that improve muscle mass and function.

Spinal Cord Injuries - complications

Humans

Muscular Atrophy - therapy

RNA, Messenger - genetics

Male

Muscle, Skeletal - innervation

Muscle, Skeletal - metabolism

Muscular Atrophy - genetics

Paralysis - genetics

Paralysis - complications

RNA, Messenger - biosynthesis

Electric Stimulation Therapy - methods

Muscle, Skeletal - physiopathology

Adult

Muscular Atrophy - etiology

Details

Title: Subtitle: Altered mRNA expression after long-term soleus electrical stimulation training in humans with paralysis
Creators: Christopher M Adams - Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Manish Suneja
Shauna Dudley-Javoroski
Richard K Shields
Resource Type: Journal article
Publication Details: Muscle & nerve, Vol.43(1), pp.65-75
DOI: 10.1002/mus.21831
PMID: 21171097
PMCID: PMC3058836
NLM abbreviation: Muscle Nerve
ISSN: 0148-639X
eISSN: 1097-4598
Publisher: United States
Grant note: R01 HD039445 / NICHD NIH HHS R01 NR010285-09 / NINR NIH HHS R01 HD062507 / NICHD NIH HHS R01 NR010285 / NINR NIH HHS R01 HD062507-01A1 / NICHD NIH HHS R01-NR-010285-08 / NINR NIH HHS R01 HD039445-04 / NICHD NIH HHS R01-HD-39445 / NICHD NIH HHS
Language: English
Date published: 01/2011
Academic Unit: Molecular Physiology and Biophysics; Orthopedics and Rehabilitation; Physical Therapy and Rehabilitation Science; Nephrology; Internal Medicine
Record Identifier: 9984025355602771

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