Journal article
Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
Molecular psychiatry, Vol.26, pp.4315-4330
2021
DOI: 10.1038/s41380-019-0631-x
PMCID: PMC7302988
PMID: 31857689
Abstract
A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d = -0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.
Details
- Title: Subtitle
- Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
- Creators
- Emily L DennisSeth G DisnerNegar FaniLauren E SalminenMark LogueEmily K ClarkeCourtney C HaswellChristopher L AverillLee A BaughJessica BomyeaSteven E BruceJiook ChaKyle ChoiNicholas D DavenportMaria DensmoreStefan du PlessisGina L ForsterJessie L FrijlingAtilla GonencStaci GruberDaniel W GrupeJeffrey P GuenetteJasmeet HayesDavid HofmannJonathan IpserTanja JovanovicSinead KellyMitzy KennisPhilipp KinzelSaskia B J KochInga KoerteSheri KoopowitzMayuresh KorgaonkarJohn KrystalLauren A M LeboisGen LiVincent A MagnottaAntje MantheyGeoff J MayDeleene S MenefeeLaura NawijnSteven M NelsonRichard W J NeufeldJack B NitschkeDaniel O'DohertyMatthew PeverillKerry J ResslerAnnerine RoosMargaret A SheridanAnika SierkAlan SimmonsRaluca M SimonsJeffrey S SimonsJennifer StevensBenjamin Suarez-JimenezDanielle R SullivanJean ThébergeJana K TranLeigh van den HeuvelSteven J A van der WerffSanne J H van RooijMirjam van ZuidenCarmen VelezMieke VerfaellieRobert R J M VermeirenBenjamin S C WadeTor WagerHenrik WalterSherry WinternitzJonathan WolffGerald YorkYe ZhuXi ZhuChadi G AbdallahRichard BryantJudith K DanielsRichard J DavidsonKelene A FerchoCarol FranzElbert GeuzeEvan M GordonMilissa L KaufmanWilliam S KremenJim LagopoulosRuth A LaniusMichael J LyonsStephen R McCauleyRegina McGlincheyKatie A McLaughlinWilliam MilbergYuval NeriaMiranda OlffSoraya SeedatMartha ShentonScott R SponheimDan J SteinMurray B SteinThomas StraubeDavid F TateNic J A van der WeeDick J VeltmanLi WangElisabeth A WildePaul M ThompsonPeter KochunovNeda JahanshadRajena A Morey
- Resource Type
- Journal article
- Publication Details
- Molecular psychiatry, Vol.26, pp.4315-4330
- DOI
- 10.1038/s41380-019-0631-x
- PMID
- 31857689
- PMCID
- PMC7302988
- ISSN
- 1359-4184
- eISSN
- 1476-5578
- Language
- English
- Date published
- 2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984229996202771
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