Journal article
Alternate Matrices: Meconium, Cord Tissue, Hair, and Oral Fluid
Methods in molecular biology (Clifton, N.J.), Vol.1872, pp.191-197
2019
DOI: 10.1007/978-1-4939-8823-5_18
PMID: 30350291
Abstract
Drug testing commonly involves serum, blood, or urine. More recently, alternative specimens for drug testing have been increasingly used for clinical and forensic toxicology. Examples include oral fluid (saliva), hair, meconium, and umbilical cord tissue. Each of these matrices has unique properties that provide advantages for certain applications. Oral fluid has easier and less invasive collection requirements than urine, the most common specimen for drug screening. Oral fluid drug testing is common in Europe and steadily gaining popularity in the United States. Hair accumulates drugs and drug metabolites and provides a much longer window of detection than blood or urine. Meconium and umbilical cord tissue each allow for assessment of prenatal drug exposure over the course of months. Limitations of these alternative matrices include need for laboratory-developed tests (exception being some oral fluid immunoassays), challenges with the specimen matrix, and incomplete understanding of drug incorporation and kinetics. This chapter briefly describes each of the above alternative specimens in terms of their utility, advantages, and limitations.
Details
- Title: Subtitle
- Alternate Matrices: Meconium, Cord Tissue, Hair, and Oral Fluid
- Creators
- Kendra L Palmer - University of Iowa Hospitals and ClinicsMatthew D Krasowski - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Methods in molecular biology (Clifton, N.J.), Vol.1872, pp.191-197
- DOI
- 10.1007/978-1-4939-8823-5_18
- PMID
- 30350291
- eISBN
- 9781493988235; 1493988239
- ISSN
- 1064-3745
- eISSN
- 1940-6029
- Language
- English
- Date published
- 2019
- Academic Unit
- Pathology
- Record Identifier
- 9984186677102771
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