Journal article
Alternative Pathway Dysfunction in Kidney Disease: A Case Report and Review of Dense Deposit Disease and C3 Glomerulopathy
American journal of kidney diseases, Vol.61(5), pp.828-831
05/2013
DOI: 10.1053/j.ajkd.2012.11.045
PMID: 23391537
Abstract
Dysfunction of the alternative pathway of complement activation provides a pathophysiologic link between the C3 glomerulopathies dense deposit disease and glomerulonephritis with C3 deposition and the clinically and histologically distinct atypical hemolytic uremic syndrome. Previously, dense deposit disease was known as membranoproliferative glomerulonephritis type II, but paucity or complete lack of immunoglobulin deposition on immunofluorescence staining and advances in our understanding of alternative pathway dysregulation have separated it from immune complex–mediated membranoproliferative glomerulonephritis types I and III. We discuss a case of dense deposit disease and review the current pathologic classification, clinical course, treatment options, and related conditions.
Details
- Title: Subtitle
- Alternative Pathway Dysfunction in Kidney Disease: A Case Report and Review of Dense Deposit Disease and C3 Glomerulopathy
- Creators
- Amret Hawfield - Wake Forest School of Medicine, Winston-Salem, NCSamy S Iskandar - Wake Forest School of Medicine, Winston-Salem, NCRichard J.H Smith - University of Iowa Carver College of Medicine, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- American journal of kidney diseases, Vol.61(5), pp.828-831
- DOI
- 10.1053/j.ajkd.2012.11.045
- PMID
- 23391537
- NLM abbreviation
- Am J Kidney Dis
- ISSN
- 0272-6386
- eISSN
- 1523-6838
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 05/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006335802771
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