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Alternative autophagy, brefeldin A and viral trafficking pathways
Journal article   Open access   Peer reviewed

Alternative autophagy, brefeldin A and viral trafficking pathways

Charles Grose and Daniel J. Klionsky
Autophagy, Vol.12(9), pp.1429-1430
09/01/2016
DOI: 10.1080/15548627.2016.1203489
PMCID: PMC5082769
PMID: 27439673
url
https://doi.org/10.1080/15548627.2016.1203489View
Published (Version of record) Open Access

Abstract

Two topics that have attracted recent attention in the field of autophagy concern the source of the membrane that is used to form the autophagosome during macroautophagy and the role of noncanonical autophagic pathways. The 2 topics may converge when considering the intersection of autophagy with viral infection. We suggest that noncanonical autophagy, which is sensitive to treatment with brefeldin A, may converge with the infectious cycles of certain DNA and RNA viruses that utilize membrane from the ER and cis-Golgi.
autophagy Beclin 1 brefeldin A coronavirus Ebola virus herpesvirus

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