Alveolar dynamics during respiration: are the pores of Kohn a pathway to recruitment?

Eman Namati; Jacqueline Thiesse; Jessica de Ryk; Geoffrey McLennan

doi:10.1165/rcmb.2007-0120OC

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Alveolar dynamics during respiration: are the pores of Kohn a pathway to recruitment?

Journal article

Open access

Peer reviewed

Alveolar dynamics during respiration: are the pores of Kohn a pathway to recruitment?

Eman Namati, Jacqueline Thiesse, Jessica de Ryk and Geoffrey McLennan

American journal of respiratory cell and molecular biology, Vol.38(5), pp.572-578

05/2008

DOI: 10.1165/rcmb.2007-0120OC

PMCID: PMC2335337

PMID: 18096874

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https://doi.org/10.1165/rcmb.2007-0120OCView

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Abstract

The change in alveolar size and number during the full breathing cycle in mammals remains unanswered, yet these descriptors are fundamental for understanding alveolar-based diseases and for improving ventilator management. Genetic and environmental mouse models are used increasingly to evaluate the evolution of disease in the peripheral lung; however, little is known regarding alveolar structure and function in the fresh, intact lung. Therefore, we have developed an optical confocal process to evaluate alveolar dynamics in the fresh intact mouse lung and as an initial experiment, have evaluated mouse alveolar dynamics during a single respiratory cycle immediately after passive lung deflation. We observe that alveoli become smaller and more numerous at the end of inspiration, and propose that this is direct evidence for alveolar recruitment in the mouse lung. The findings reported support a new hypothesis that requires recruitable secondary (daughter) alveoli to inflate via primary (mother) alveoli rather than from a conducting airway.

Catheterization

Mice, Inbred C57BL

Pulmonary Alveoli - physiology

Pleura - physiology

Pleura - anatomy & histology

Microscopy, Confocal

Biomechanical Phenomena

Animals

Mice

In Vitro Techniques

Pulmonary Alveoli - anatomy & histology

Respiration

Tidal Volume - physiology

Details

Title: Subtitle: Alveolar dynamics during respiration: are the pores of Kohn a pathway to recruitment?
Creators: Eman Namati - Internal Medicine, University of Iowa, 200 Hawkins Drive, C325 GH, Iowa City, IA 52242, USA
Jacqueline Thiesse
Jessica de Ryk
Geoffrey McLennan
Resource Type: Journal article
Publication Details: American journal of respiratory cell and molecular biology, Vol.38(5), pp.572-578
DOI: 10.1165/rcmb.2007-0120OC
PMID: 18096874
PMCID: PMC2335337
NLM abbreviation: Am J Respir Cell Mol Biol
ISSN: 1044-1549
eISSN: 1535-4989
Publisher: United States
Grant note: CA91085-05 / NCI NIH HHS
Language: English
Date published: 05/2008
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology
Record Identifier: 9984051725502771

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