Journal article
Amastatin potentiates drinking elicited by osmotic stimuli: evidence for peptidergic mediation of intracellular dehydration-induced thirst
Brain research, Vol.590(1-2), pp.271-276
09/1992
DOI: 10.1016/0006-8993(92)91105-N
PMID: 1422835
Abstract
Aminopeptidase inhibitors have been demonstrated to enhance the behavioral effects of both exogenously applied and endogenously released neuropeptides. In this study peptidase inhibitors were used as probes for involvement of central neuropeptides in osmotically-induced drinking behavior. Intracerebroventricular (i.c.v.) injections of amastatin, an aminopeptidase A inhibitor, potentiated water intake induced by subcutaneous injections of hypertonic saline. Drinking responses to i.c.v. infusions of hypertonic saline were also enhanced when amastatin was added to the infusions. The effect was not attenuated by the angiotensin receptor antagonist, [Sar1, Thr8]angiotensin II, which suggests that angiotensins do not play a role in the over-drinking. Drinking responses to centrally infused hypertonic saline were not enhanced by i.c.v. thiorphan, an endopeptidase inhibitor; this provides evidence that the effects of amastatin are specific for a particular class of peptidases. These results suggest that there is a role for an endogenous, non-angiotensinergic brain peptide in the mediation of osmotic thirst. © 1992.
Details
- Title: Subtitle
- Amastatin potentiates drinking elicited by osmotic stimuli: evidence for peptidergic mediation of intracellular dehydration-induced thirst
- Creators
- Margaret J SullivanAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.590(1-2), pp.271-276
- DOI
- 10.1016/0006-8993(92)91105-N
- PMID
- 1422835
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 09/1992
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213406402771
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