Journal article
Amastatin potentiation of drinking induced by blood-borne angiotensin: evidence for mediation by endogenous brain angiotensin
Brain research, Vol.510(2), pp.237-241
1990
DOI: 10.1016/0006-8993(90)91373-O
PMID: 2331601
Abstract
Angiotensinergic synapses in the central nervous system (CNS) have been proposed to be involved in drinking induced by both intracerebroventricular (i.c.v.) and peripheral administration of angiotensins. In the present studies, we tested this hypothesis with i.c.v. application of amastatin, an aminopeptidase A inhibitor, to block peptide degradation. Potentiation of i.c.v. angiotensin II (Ang II)-induced drinking responses was observed when amastatin and Ang II were administered. Amastatin did not potentiate drinking to carbachol which demonstrates that the enhancement is specific to peptides. Centrally administered amastatin also potentiated drinking following systematic administration of Asn
1 angiotensin II. (Asn
1 Ang II). The results are consistent with the hypothesis that CNS angiotensin synapses are involved in the dipsogenic response that results from elevated levels of circulating angiotensin.
Details
- Title: Subtitle
- Amastatin potentiation of drinking induced by blood-borne angiotensin: evidence for mediation by endogenous brain angiotensin
- Creators
- Margaret J SullivanTerry G BeltzAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.510(2), pp.237-241
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0006-8993(90)91373-O
- PMID
- 2331601
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1990
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213272002771
Metrics
13 Record Views