Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis

Jennifer C D'Souza; Steven M Kawut; Laura R Elkayam; Lianne Sheppard; Peter S Thorne; David R Jacobs Jr; David A Bluemke; Joao A C Lima; Joel D Kaufman; Timothy V Larson; Sara D Adar

doi:10.1289/EHP658

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Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis

Journal article

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Peer reviewed

Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis

Jennifer C D'Souza, Steven M Kawut, Laura R Elkayam, Lianne Sheppard, Peter S Thorne, David R Jacobs Jr, David A Bluemke, Joao A C Lima, Joel D Kaufman, Timothy V Larson, …

Environmental health perspectives, Vol.125(7), pp.077019-077019

07/27/2017

DOI: 10.1289/EHP658

PMCID: PMC5744657

PMID: 28760719

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Abstract

Coarse particulate matter (P ) is primarily mechanically generated and includes crustal material, brake and tire wear, and biological particles. PM is associated with pulmonary disease, which can lead to right ventricular (RV) dysfunction. Although RV characteristics have been associated with combustion-related pollutants, relationships with PM remain unknown. To quantify cross-sectional associations between RV dysfunction and PM mass and components among older adults and susceptible populations. We used baseline cardiac magnetic resonance images from 1,490 participants (45-84 y old) from the Multi-Ethnic Study of Atherosclerosis and assigned 5-y residential concentrations of PM mass, copper, zinc, phosphorus, silicon, and endotoxin, using land-use regression models. We quantified associations with RV mass, end-diastolic volume, and ejection fraction after control for risk factors and copollutants using linear regression. We further examined personal susceptibility. We found positive associations of RV mass and, to a lesser extent, end diastolic volume with PM mass among susceptible populations including smokers and persons with emphysema. After adjustment for copollutants, an interquartile range increase in PM mass (2.2 μg/m ) was associated with 0.5 g (95% CI: 0.0, 1.0), 0.9 g (95% CI: 0.1, 1.7), and 1.4 g (95% CI: 0.4, 2.5) larger RV mass among former smokers, current smokers, and persons with emphysema, respectively. No associations were found with healthy individuals or with ejection fraction. Alterations to RV structure may represent a mechanism by which long-term PM exposure increases risks for adverse respiratory and cardiovascular outcomes, especially among certain susceptible populations. https://doi.org/10.1289/EHP658.

Particulate Matter - toxicity

Cross-Sectional Studies

Atherosclerosis - physiopathology

Atherosclerosis - chemically induced

Humans

Middle Aged

Risk Factors

Male

Atherosclerosis - ethnology

Environmental Exposure

Minnesota - epidemiology

Particle Size

Ventricular Dysfunction, Right - ethnology

Aged, 80 and over

Female

Ventricular Dysfunction, Right - physiopathology

Aged

Chicago - epidemiology

Environmental Pollutants - toxicity

Ventricular Dysfunction, Right - chemically induced

North Carolina - epidemiology

Details

Title: Subtitle: Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis
Creators: Jennifer C D'Souza - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Steven M Kawut - Department of Medicine, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Laura R Elkayam - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Lianne Sheppard - Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA
Peter S Thorne - Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa, USA
David R Jacobs Jr - Department of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA
David A Bluemke - Radiology and Imaging Sciences, National Institute of Biomedical Imaging and Bioengineering, Bethesda, Maryland, USA
Joao A C Lima - Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Joel D Kaufman - Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Timothy V Larson - Department of Civil and Environmental Engineering, University of Washington College of Engineering, Seattle, Washington, USA
Sara D Adar - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Resource Type: Journal article
Publication Details: Environmental health perspectives, Vol.125(7), pp.077019-077019
Publisher: United States
DOI: 10.1289/EHP658
PMID: 28760719
PMCID: PMC5744657
ISSN: 0091-6765
eISSN: 1552-9924
Grant note: R01 HL071759 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS N01HC95169 / NHLBI NIH HHS K24 ES013195 / NIEHS NIH HHS UL1 RR025005 / NCRR NIH HHS N01HC95161 / NHLBI NIH HHS N01HC95164 / NHLBI NIH HHS HHSN268201500003C / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS N01HC95167 / NHLBI NIH HHS RC1 HL100543 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS R01 HL077612 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS N01HC95168 / NHLBI NIH HHS UL1 TR000040 / NCATS NIH HHS N01HC95165 / NHLBI NIH HHS P30 ES007033 / NIEHS NIH HHS R01 HL086719 / NHLBI NIH HHS N01HC95162 / NHLBI NIH HHS
Language: English
Date published: 07/27/2017
Academic Unit: Civil and Environmental Engineering; Occupational and Environmental Health
Record Identifier: 9983997369302771

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