Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa

Marvin E Langston; Heidi E Brown; Charles F Lynch; Denise J Roe; Leslie K Dennis

doi:10.3390/ijerph19031742

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Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa

Journal article

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Peer reviewed

Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa

Marvin E Langston, Heidi E Brown, Charles F Lynch, Denise J Roe and Leslie K Dennis

International journal of environmental research and public health, Vol.19(3), p.1742

02/03/2022

DOI: 10.3390/ijerph19031742

PMCID: PMC8835255

PMID: 35162766

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Abstract

Intermittent sun exposure is the major environmental risk factor for cutaneous melanoma (CM). Cumulative sun exposure and other environmental agents, such as environmental arsenic exposure, have not shown consistent associations. Ambient ultraviolet radiation (UVR) was used to measure individual total sun exposure as this is thought to be less prone to misclassification and recall bias. Data were analyzed from 1096 CM cases and 1033 controls in the Iowa Study of Skin Cancer and Its Causes, a population-based, case-control study. Self-reported residential histories were linked to satellite-derived ambient UVR, spatially derived environmental soil arsenic concentration, and drinking water arsenic concentrations. In men and women, ambient UVR during childhood and adolescence was not associated with CM but was positively associated during adulthood. Lifetime ambient UVR was positively associated with CM in men (OR for highest vs. lowest quartile: 6.09, 95% confidence interval (CI) 2.21-16.8), but this association was not as strong among women (OR for highest vs. lowest quartile: 2.15, 95% CI 0.84-5.54). No association was detected for environmental soil or drinking water arsenic concentrations and CM. Our findings suggest that lifetime and adulthood sun exposures may be important risk factors for CM.

ultraviolet radiation

melanoma

sun exposure

arsenic

Details

Title: Subtitle: Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa
Creators: Marvin E Langston - Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA
Heidi E Brown - Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA
Charles F Lynch - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
Denise J Roe - Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USA
Leslie K Dennis - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: International journal of environmental research and public health, Vol.19(3), p.1742
DOI: 10.3390/ijerph19031742
PMID: 35162766
PMCID: PMC8835255
NLM abbreviation: Int J Environ Res Public Health
ISSN: 1661-7827
eISSN: 1660-4601
Grant note: R01CA118493 and R01CA118493 Supplement / NCI NIH HHS
Language: English
Date published: 02/03/2022
Academic Unit: Epidemiology
Record Identifier: 9984216625402771

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