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Ameliorative potential of aliskiren in experimental colitis in mice
Journal article   Peer reviewed

Ameliorative potential of aliskiren in experimental colitis in mice

Rakesh B Patel, Kanaiyalal D Prajapati, Bhavin M Sonara, Manoranjan M Sharma, Hiren M Patel, Vishwanath D Pawar and Mukul R Jain
European journal of pharmacology, Vol.737, pp.70-76
08/15/2014
DOI: 10.1016/j.ejphar.2014.05.009
PMID: 24858618

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Abstract

In the present study, we investigated the ameliorative potential of aliskiren in dextran sulfate sodium (DSS) induced colitis in mice. Aliskiren (3 and 10mg/kg, i.p.) was administered for 10 days from the day of DSS administration. The severity of colitis in mice was assessed using body weight loss, colon and spleen weight, hematological parameters, food intake, stool consistency, rectal bleeding and colon shortening. Colonic malondialdehyde (MDA), myeloperoxidase (MPO) and renin mRNA levels were also estimated. Furthermore, TNF-α and IL-6 in plasma and colon were analyzed. The results showed that aliskiren (10mg/kg, i.p.) significantly improved the severity of colitis by, decrease in weight loss, improvement in food intake and stool consistency, decrease in rectal bleeding, decrease in relative colon and spleen weight and improvement in colonic shortening. Aliskiren (10mg/kg, i.p.) improved blood hemoglobin, red blood cells (RBC) and hematocrit. Colonic malondialdehyde (MDA), MPO and histolopathological score were significantly diminished by aliskiren (10mg/kg, i.p.). Furthermore, aliskiren (10mg/kg, i.p.) significantly diminished the elevated levels of TNF-α, IL-6 and renin mRNA in inflammed colon. These results indicate involvement of renin in colitis and inhibition of renin by aliskiren ameliorates colitis.
 Amides - pharmacology Amides - therapeutic use Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antioxidants - pharmacology Antioxidants - therapeutic use Body Weight - drug effects Colitis - blood Colitis - chemically induced Colitis - drug therapy Colitis - pathology Colon - drug effects Colon - pathology Cytokines - metabolism Dextran Sulfate - adverse effects Eating - drug effects Erythrocytes - drug effects Female Fumarates - pharmacology Fumarates - therapeutic use Gene Expression Regulation - drug effects Hematocrit Hemoglobins - metabolism Malondialdehyde - metabolism Mice Organ Size - drug effects Peroxidase - metabolism Renin - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Spleen - drug effects Spleen - pathology

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