American Academy of Periodontology best evidence consensus statement on the use of biologics in clinical practice

Gustavo Avila-Ortiz; Jeanne Ambruster; Shayan Barootchi; Leandro Chambrone; Chia-Yu Chen; Douglas R. Dixon; Maria L. Geisinger; William Giannobile; Katie Goss; John C. Gunsolley; Rick H. Heard; David M. Kim; George A. Mandelaris; Alberto Monje; Marc L. Nevins; Angela Palaiologou-Gallis; Paul S. Rosen; Todd E Scheyer; Fernando Suarez-Lopez del Amo; Lorenzo Tavelli; Diego Velasquez; Hom-Lay Wang; Brian L. Mealey

doi:10.1002/JPER.22-0361

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American Academy of Periodontology best evidence consensus statement on the use of biologics in clinical practice

Journal article

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American Academy of Periodontology best evidence consensus statement on the use of biologics in clinical practice

Gustavo Avila-Ortiz, Jeanne Ambruster, Shayan Barootchi, Leandro Chambrone, Chia-Yu Chen, Douglas R. Dixon, Maria L. Geisinger, William Giannobile, Katie Goss, John C. Gunsolley, …

Journal of periodontology (1970), Vol.93(12), pp.1763-1770

10/24/2022

DOI: 10.1002/JPER.22-0361

PMCID: PMC10091815

PMID: 36279407

Appears in UI Libraries Support Open Access

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Abstract

A biologic is a therapeutic agent with biological activity that is administered to achieve an enhanced regenerative or reparative effect. The use of biologics has progressively become a core component of contemporary periodontal practice. However, some questions remain about their safety, indications, and effectiveness in specific clinical scenarios. Given their availability for routine clinical use and the existing amount of related evidence, the goal of this American Academy of Periodontology (AAP) best evidence consensus (BEC) was to provide a state-of-the-art, evidence-based perspective on the therapeutic application of autologous blood-derived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet-derived growth factor BB (rhPDGF-BB), and recombinant human bone morphogenetic protein 2 (rhBMP-2). A panel of experts with extensive knowledge on the science and clinical application of biologics was convened. Three systematic reviews covering the areas of periodontal plastic surgery, treatment of infrabony defects, and alveolar ridge preservation/reconstruction and implant site development were conducted a priori and provided the foundation for the deliberations. The expert panel debated the merits of published data and exchanged experiential information to formulate evidence-based consensus statements and recommendations for clinical practice and future research. Based on an analysis of the current evidence and expert opinion, the panel concluded that the appropriate use of biologics in periodontal practice is generally safe and provides added benefits to conventional treatment approaches. However, therapeutic benefits and risks range based on the specific biologics used as well as patient-related local and systemic factors. Given the limited evidence available for some indications (e.g., gingival augmentation therapy, alveolar ridge preservation/reconstruction, and implant site development), future clinical studies that can expand the knowledge base on the clinical use of biologics in periodontal practice are warranted.

Dentistry, Oral Surgery & Medicine

Life Sciences & Biomedicine

Science & Technology

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Title: Subtitle: American Academy of Periodontology best evidence consensus statement on the use of biologics in clinical practice
Creators: Gustavo Avila-Ortiz - University of Iowa
Jeanne Ambruster - The Avenues Company, Flagstaff, Arizona, USA.
Shayan Barootchi - University of Michigan
Leandro Chambrone - University of Iowa
Chia-Yu Chen - Harvard University
Douglas R. Dixon - University of Tennessee Health Science Center
Maria L. Geisinger - University of Alabama at Birmingham
William Giannobile - Harvard University
Katie Goss - American Academy of Periodontology Foundation
John C. Gunsolley - Virginia Commonwealth University
Rick H. Heard - Private Practice, Victoria, Texas, USA.
David M. Kim - Harvard University
George A. Mandelaris - University of Michigan
Alberto Monje - University of Michigan
Marc L. Nevins - Harvard University
Angela Palaiologou-Gallis - The University of Texas Health Science Center at San Antonio
Paul S. Rosen - Rutgers, The State University of New Jersey
Todd E Scheyer - Univ Texas Sch Dent Houston, Houston, TX USA
Fernando Suarez-Lopez del Amo
Lorenzo Tavelli - Harvard University
Diego Velasquez - University of Michigan
Hom-Lay Wang - University of Michigan
Brian L. Mealey - The University of Texas Health Science Center at San Antonio
Resource Type: Journal article
Publication Details: Journal of periodontology (1970), Vol.93(12), pp.1763-1770
DOI: 10.1002/JPER.22-0361
PMID: 36279407
PMCID: PMC10091815
NLM abbreviation: J Periodontol
ISSN: 0022-3492
eISSN: 1943-3670
Publisher: Wiley
Number of pages: 8
Grant note: Geistlich Biomaterials (Princeton, New Jersey) Straumann USA (Andover, Massachusetts) BioHorizons (Birmingham, Alabama) Lynch Biologics (Franklin, Tennessee)
Language: English
Date published: 10/24/2022
Academic Unit: Periodontics
Record Identifier: 9984323337902771

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