Journal article
Ammonia potentiates GABAA response in dissociated rat cortical neurons
Neuroscience letters, Vol.151(1), pp.51-54
03/1993
DOI: 10.1016/0304-3940(93)90043-K
PMID: 8385761
Abstract
The ammonium ion (NH4+) evoked no response itself but facilitated the GABA-induced Cl- current (ICl) in dissociated rat cortical neurons. The GABA concentration-response curve shifted parallely to the left without changing the maximum response. Reversal potential of GABA response did not change in the presence of NH4+ at the concentration range between 0.1 and 1 mM. Ro 15-1788, a selective benzodiazepine receptor antagonist, did not affect the facilitatory action of NH4+ on GABAA receptor. The results suggest that NH4+ modifies the affinity of GABAA receptor for GABA, without the involvement of benzodiazepine receptors.
Details
- Title: Subtitle
- Ammonia potentiates GABAA response in dissociated rat cortical neurons
- Creators
- Kazuyoshi TakahashiHiroyuki KamedaMikiko KataokaKenshou SanjouNobutoshi HarataNorio Akaike
- Resource Type
- Journal article
- Publication Details
- Neuroscience letters, Vol.151(1), pp.51-54
- DOI
- 10.1016/0304-3940(93)90043-K
- PMID
- 8385761
- ISSN
- 0304-3940
- eISSN
- 1872-7972
- Language
- English
- Date published
- 03/1993
- Academic Unit
- Molecular Physiology and Biophysics
- Record Identifier
- 9984025440502771
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