Journal article
Amoxicillin use during early childhood and fluorosis of later developing tooth zones
Journal of Public Health Dentistry, Vol.71(3), pp.229-235
2011
DOI: 10.1111/j.1752-7325.2011.00254.x
PMID: 21972463
Abstract
Objectives: Amoxicillin use has been reported to be associated with developmental defects on enamel surfaces. This analysis assessed the association between amoxicillin use and fluorosis on late‐erupting permanent teeth. Methods: As part of the Iowa Fluoride Study, subjects were followed from birth to 32 months with questionnaires every 3‐4 months to gather information on fluoride intake and amoxicillin use (n = 357 subjects for this analysis). Permanent tooth fluorosis on late‐erupting zones was assessed by three trained dentists using the fluorosis risk index (FRI) at approximately age 13. A case was defined as fluorosis if a subject had at least two FRI classification II zone scores of 2 or 3. Chi‐square tests and logistic regression were used, and relative risks (RRs) and odds ratios (ORs) were calculated. Results: There were 113 cases and 244 controls. In bivariate analyses, amoxicillin use from 20 to 24 months significantly increased the risk of fluorosis on FRI classification II zones [44.2 percent versus 30.4 percent, [RR = 1.45, 95 percent confidence interval (CI) 1.05‐2.04], but other individual time periods did not. Multivariable logistic regression confirmed the increased risk of fluorosis for amoxicillin use from 20 to 24 months (OR = 2.92, 95 percent CI = 1.34‐6.40), after controlling for otitis media, breast‐feeding, and fluoride intake. Conclusions: Amoxicillin use during early childhood could be a risk factor in the etiology of fluorosis on late‐erupting permanent tooth zones, but further research is needed.
Details
- Title: Subtitle
- Amoxicillin use during early childhood and fluorosis of later developing tooth zones
- Creators
- Liang HongSteven M LevyJohn J WarrenBarbara Broffitt
- Resource Type
- Journal article
- Publication Details
- Journal of Public Health Dentistry, Vol.71(3), pp.229-235
- DOI
- 10.1111/j.1752-7325.2011.00254.x
- PMID
- 21972463
- NLM abbreviation
- J Public Health Dent
- ISSN
- 0022-4006
- eISSN
- 1752-7325
- Publisher
- Blackwell Publishing Inc; Malden, USA
- Number of pages
- 7
- Language
- English
- Date published
- 2011
- Academic Unit
- Preventive and Community Dentistry; Epidemiology
- Record Identifier
- 9983917665102771
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