Journal article
Ampicillin/Sulbactam and Cefoxitin in the Treatment of Cutaneous and Other Soft-Tissue Abscesses in Patients With or Without Histories of Injection Drug Abuse
Clinical infectious diseases, Vol.31(2), pp.464-471
08/2000
DOI: 10.1086/313971
PMID: 10987706
Abstract
A randomized, double-blind trial compared the clinical and bacteriologic efficacy of ampicillin/sulbactam (2 g/1 g) and cefoxitin (2 g) administered intravenously every 6 h to patients with (n = 49) or without (n = 47) histories of injection drug abuse who presented with cutaneous or other soft-tissue infections. Cure or improvement occurred in 89.8% of ampicillin/sulbactam-treated patients, compared with 93.6% of cefoxitin-treated patients. The median time to resolution of all symptoms was 10.5 days with ampicillin/sulbactam treatment and 15.5 days with cefoxitin treatment. Mixed aerobic-anaerobic infection was encountered frequently in both treatment groups. A significantly higher percentage of Streptococcus species was found in the major abscesses of the patients with histories of injection drug abuse, compared with those without such histories (37% vs. 19%, respectively; P = .0009). Overall, ampicillin/sulbactam eradicated pathogens from the major abscesses in 100% of patients, whereas the eradication rate with cefoxitin was 97.9%. The 2 drugs were well tolerated. Ampicillin/sulbactam and cefoxitin were equally effective for the empirical treatment of cutaneous or other soft-tissue infections in injection drug abusers and patients who did not inject drugs.
Details
- Title: Subtitle
- Ampicillin/Sulbactam and Cefoxitin in the Treatment of Cutaneous and Other Soft-Tissue Abscesses in Patients With or Without Histories of Injection Drug Abuse
- Creators
- David A. Talan - Los Angeles Medical CenterPaula H. Summanen - West Los Angeles CollegeSydney M. Finegold - West Los Angeles College
- Resource Type
- Journal article
- Publication Details
- Clinical infectious diseases, Vol.31(2), pp.464-471
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/313971
- PMID
- 10987706
- ISSN
- 1058-4838
- eISSN
- 1537-6591
- Language
- English
- Date published
- 08/2000
- Academic Unit
- Emergency Medicine; Internal Medicine
- Record Identifier
- 9984296971402771
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