Journal article
Amplification of 9p24.1 in diffuse large B-cell lymphoma identifies a unique subset of cases that resemble primary mediastinal large B-cell lymphoma
Blood cancer journal (New York), Vol.9(9), pp.73-11
08/30/2019
DOI: 10.1038/s41408-019-0233-5
PMCID: PMC6717207
PMID: 31471540
Abstract
Copy number alterations (CNAs) of 9p24.1 occur frequently in Hodgkin lymphoma, primary mediastinal large B-cell lymphoma (PMBCL), primary central nervous system lymphoma, and primary testicular lymphoma, resulting in overexpression of PD-L1 and sensitivity to PD-1 blockade-based immunotherapy. While 9p24.1 CNA was also reported in diffuse large B-cell lymphoma (DLBCL), little is known about its molecular or clinical significance. In this study, we analyzed the prevalence of 9p24.1 CNA in newly diagnosed DLBCL and examined its association with PD-L1, PD-L2, and JAK2 expression, clinical characteristics, and outcome. We found that 10% of DLBCL cases had CNA of 9p24.1, with 6.5% gains, and 3.5% amplifications. Only the cases with a 9p24.1 amplification had high levels of PD-L1, PD-L2, and JAK2 expression. Gains or amplifications of 9p24.1 were associated with a younger age and the ABC/non-GCB subtype. Compared with DLBCL cases without 9p24.1 CNA, the cases with a 9p24.1 amplification had a trend of better event-free survival. Furthermore, the amplification cases had a gene expression and mutation profile similar to those of PMBCL. Our data suggest that amplification of 9p24.1 identifies a unique subset of DLBCL with clinical and molecular features resembling PMBCL that may be amenable to PD-1 blockade-based immunotherapy.
Details
- Title: Subtitle
- Amplification of 9p24.1 in diffuse large B-cell lymphoma identifies a unique subset of cases that resemble primary mediastinal large B-cell lymphoma
- Creators
- Yucai Wang - Mayo Clinic in FloridaKerstin Wenzl - Mayo Clinic in FloridaMichelle K Manske - Mayo Clinic in FloridaYan W Asmann - Mayo Clinic in FloridaVivekananda Sarangi - Mayo Clinic in FloridaPatricia T Greipp - Division of Laboratory Genetics and Genomics; Mayo Clinic; Rochester MN USAJordan E Krull - Mayo Clinic in FloridaKeenan Hartert - Mayo Clinic in FloridaRong He - Mayo Clinic in FloridaAndrew L Feldman - Mayo Clinic in FloridaMatthew J Maurer - Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USASusan L Slager - Mayo ClinicGrzegorz S Nowakowski - Mayo ClinicThomas M Habermann - Mayo ClinicThomas E Witzig - Mayo Clinic in FloridaBrian K Link - University of IowaStephen M Ansell - Mayo ClinicJames R Cerhan - Mayo Clinic in FloridaAnne J Novak - Division of Hematology, Mayo Clinic, Rochester, USA,
- Resource Type
- Journal article
- Publication Details
- Blood cancer journal (New York), Vol.9(9), pp.73-11
- DOI
- 10.1038/s41408-019-0233-5
- PMID
- 31471540
- PMCID
- PMC6717207
- NLM abbreviation
- Blood Cancer J
- ISSN
- 2044-5385
- eISSN
- 2044-5385
- Grant note
- U01 CA195568 / NCI NIH HHS T32 AI007425 / NIAID NIH HHS R01 CA212162 / NCI NIH HHS P30 CA086862 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
- Language
- English
- Date published
- 08/30/2019
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984359825802771
Metrics
20 Record Views