Journal article
Amygdala-cingulate intrinsic connectivity is associated with degree of social inhibition
Biological psychology, Vol.99(1), pp.15-25
05/01/2014
DOI: 10.1016/j.biopsycho.2014.02.003
PMCID: PMC4274047
PMID: 24534162
Abstract
The tendency to approach or avoid novel people is a fundamental human behavior and is a core dimension of social anxiety. Resting state fMRI was used to test for an association between social inhibition and intrinsic connectivity in 40 young adults ranging from low to high in social inhibition. Higher levels of social inhibition were associated with specific patterns of reduced amygdala-cingulate cortex connectivity. Connectivity was reduced between the superficial amygdala and the rostral cingulate cortex and between the centromedial amygdala and the dorsal anterior cingulate cortex. Social inhibition also modulated connectivity in several well-established intrinsic networks; higher social inhibition correlated with reduced connectivity with default mode and dorsal attention networks and enhanced connectivity in salience and executive control networks. These findings provide important preliminary evidence that social inhibition reflects differences in the underlying intrinsic connectivity of the brain in the absence of social stimuli or stressors. (C) 2014 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Amygdala-cingulate intrinsic connectivity is associated with degree of social inhibition
- Creators
- Jennifer Urbano Blackford - Vanderbilt UniversityJacqueline A. Clauss - Vanderbilt UniversitySuzanne N. Avery - Vanderbilt UniversityRonald L. Cowan - Vanderbilt UniversityMargaret M. Benningfield - Vanderbilt UniversityRoss M. VanDerKlok - Vanderbilt University
- Resource Type
- Journal article
- Publication Details
- Biological psychology, Vol.99(1), pp.15-25
- DOI
- 10.1016/j.biopsycho.2014.02.003
- PMID
- 24534162
- PMCID
- PMC4274047
- NLM abbreviation
- Biol Psychol
- ISSN
- 0301-0511
- eISSN
- 1873-6246
- Publisher
- Elsevier
- Number of pages
- 11
- Grant note
- RR024975; RR024978 / Vanderbilt Institute for Clinical and Translational Research; Vanderbilt University University of West Alabama Shire Pharmaceuticals Vanderbilt University Institute of Imaging Science; Vanderbilt University GM07347 / Vanderbilt Medical Scientist Training Program (National Institute of General Medical Studies); Vanderbilt University Southwest Michigan First Life Science Fund MH083052; MH097344; MH102008; MH073800; MH018921 / National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) DA015137; DA020149; DA000357 / National Institute of Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) Novo Nordisk; Novo Nordisk Foundation
- Language
- English
- Date published
- 05/01/2014
- Academic Unit
- Psychiatry
- Record Identifier
- 9985222824902771
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