Journal article
Amygdala volume correlates positively with fearfulness in normal healthy girls
Social cognitive and affective neuroscience, Vol.5(4), pp.424-431
12/2010
DOI: 10.1093/scan/nsq009
PMCID: PMC2999759
PMID: 20150341
Abstract
Research into the neural underpinnings of fear and fear-related pathology has highlighted the role of the amygdala. For instance, bilateral damage to the amygdaloid complex is associated with decreased appreciation of danger and recognition of fear in humans, whereas enlarged amygdala volume is associated with internalizing syndromes. It is unknown whether amygdala volume and fearfulness are related in the absence of pathology. We examined the correlation between normal fearfulness and amygdala morphology in 116 healthy children and adolescents (60 boys, 56 girls, age 7–17 years). Fearfulness was measured using the parent ratings on the Pediatric Behavior Scale and amygdala volumes were determined by manual tracing. We found a positive correlation between right amygdala volume in girls (
r
= 0.29). This relationship was more robust and present bilaterally when analyses were limited to girls with a positive nuclear family history of depression (for left
r
= 0.63; for right
r
= 0.58). In boys there was no significant relationship which may suggest that biological mechanisms differ between sexes. Given the role of enlarged amygdala volume in pathology, these findings may indicate that variation in amygdala morphology marks susceptibility to internalizing disorders.
Details
- Title: Subtitle
- Amygdala volume correlates positively with fearfulness in normal healthy girls
- Creators
- Ellen A. A van der Plas - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City 52242, IowaAaron D Boes - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City 52242, IowaJohn A Wemmie - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City 52242, IowaDaniel Tranel - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City 52242, IowaPeg Nopoulos - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City 52242, Iowa
- Resource Type
- Journal article
- Publication Details
- Social cognitive and affective neuroscience, Vol.5(4), pp.424-431
- DOI
- 10.1093/scan/nsq009
- PMID
- 20150341
- PMCID
- PMC2999759
- NLM abbreviation
- Soc Cogn Affect Neurosci
- ISSN
- 1749-5016
- eISSN
- 1749-5024
- Publisher
- Oxford University Press
- Language
- English
- Date published
- 12/2010
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurology (Pediatrics); Neurosurgery
- Record Identifier
- 9984002481302771
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