Amygdalar and hippocampal volumetry in control participants: differences regarding handedness

C. Akos Szabo; Jinhu Xiong; Jack L Lancaster; Lacy Rainey; Peter  Fox

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Amygdalar and hippocampal volumetry in control participants: differences regarding handedness

Journal article

Peer reviewed

Amygdalar and hippocampal volumetry in control participants: differences regarding handedness

C. Akos Szabo, Jinhu Xiong, Jack L Lancaster, Lacy Rainey and Peter Fox

American journal of neuroradiology : AJNR, Vol.22(7), pp.1342-1345

08/2001

PMCID: PMC7975203

PMID: 11498423

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Abstract

Amygdalar and hippocampal volume measurements indicate a right-greater-than-left asymmetry for right-handed normal participants in most studies. The purpose of this study was to compare amygdalar and hippocampal volume ratios between right- and left-handed participants. Amygdalar and hippocampal volume measurements were performed in 34 (20 right-handed and 14 left-handed) normal participants. All participants completed a 10-item handedness questionnaire. The MR imaging sequence was a 3D T1-weighted gradient-echo acquisition of the whole brain (24/6 [TR/TE]; flip angle, 25 degrees). MR images were spatially normalized, and volumes were painted with a 1.0-mm(3) resolution cursor on an SGI workstation. In right-handed participants, the amygdala and hippocampus (P <.001 for both) were significantly larger on the right side than on the left. The left-handed group did not show a significant difference between right- and left-sided structures. Right-to-left volume ratios differed significantly between right- and left-handed participants for both amygdalar (P <.02) and hippocampal (P <.01) structures. Gender did not affect right-to-left amygdalar and hippocampal volume ratios in right- or left-handed participants. Handedness, but not gender, seems to affect right-to-left amygdalar and hippocampal volume ratios.

Magnetic Resonance Imaging

Amygdala - anatomy & histology

Image Processing, Computer-Assisted

Humans

Adult

Female

Male

Reference Values

Cephalometry

Functional Laterality - physiology

Hippocampus - anatomy & histology

Imaging, Three-Dimensional

Details

Title: Subtitle: Amygdalar and hippocampal volumetry in control participants: differences regarding handedness
Creators: C. Akos Szabo - Division of Neurology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
Jinhu Xiong
Jack L Lancaster
Lacy Rainey
Peter Fox
Resource Type: Journal article
Publication Details: American journal of neuroradiology : AJNR, Vol.22(7), pp.1342-1345
PMID: 11498423
PMCID: PMC7975203
ISSN: 0195-6108
eISSN: 1936-959X
Grant note: P20 DA52176 / NIDA NIH HHS
Language: English
Date published: 08/2001
Academic Unit: Roy J. Carver Department of Biomedical Engineering
Record Identifier: 9984083235402771

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