An Active Focus of High Prevalence of Fogo Selvagem on an Amerindian Reservation in Brazil

Gunter Hans-Filho; Vandir dos Santos; Joana H. Katayama; Valeria Aoki; Evandro A. Rivitti; Sebastiao A.P. Sampaio; Horacio Friedman; Jose R. Moraes; Maria E. Moraes; Donald P. Eaton; Argelia L. Lopez; Raymond G. Hoffman; Janet A. Fairley; George J. Giudice; Luis A. Diaz; Cooperative Group on Fogo Selvagem Research

doi:10.1111/1523-1747.ep12298213

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An Active Focus of High Prevalence of Fogo Selvagem on an Amerindian Reservation in Brazil

Journal article

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An Active Focus of High Prevalence of Fogo Selvagem on an Amerindian Reservation in Brazil

Gunter Hans-Filho, Vandir dos Santos, Joana H. Katayama, Valeria Aoki, Evandro A. Rivitti, Sebastiao A.P. Sampaio, Horacio Friedman, Jose R. Moraes, Maria E. Moraes, Donald P. Eaton, …

Journal of investigative dermatology, Vol.107(1), pp.68-75

07/1996

DOI: 10.1111/1523-1747.ep12298213

PMID: 8752842

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Abstract

Fogo Selvagem (FS) is an autoimmune disease characterized by subcorneal vesicles and antidesmoglein-1 autoantibodies. Previous epidemiologic data have linked the onset of FS to exposure to an environmental antigen(s). This investigation describes a unique human settlement with an extraordinarily high prevalence of FS, This community is made up of Amerindians belonging to the Terena tribe, which has settled on the Limao Verde reservation in the state of Mato Grosso do Sul in Brazil. Twenty-six well-characterized FS cases have been identified within a total population of 998, yielding a prevalence of 2.6%. Seventeen of the patients (65%) were males, and over 50% were older than 30 y of age. The incidence of the disease shows temporal periodicity, i.e., years with several cases of FS alternating with years with no cases. Over one-half of the cases occurred in genetically related family members. Another Terena reservation, the Ipegue/Taunay, located 90km west of the Limao Verde reservation, with a population of 2203, had no recorded cases of FS. Thus, the Limao Verde reservation represents a new focus of FS in which the disease exhibits temporal, geographic, and familial clustering. These results suggest that the environmental antigen or antigens precipitating FS are endemic to the Limao Verde reservation. This reservation appears to be an ideal population for carrying out sero-epidemiologic, genetic, and environmental studies aimed at disclosing the etiology of FS.

Epidemiology

Etiology

pemphigus foliaccus

Details

Title: Subtitle: An Active Focus of High Prevalence of Fogo Selvagem on an Amerindian Reservation in Brazil
Creators: Gunter Hans-Filho - Universidade Federal de Mato Grosso do Sul
Vandir dos Santos - Secretaria de Estado de Saude do Mato Grosso do Sul, Brazil
Joana H. Katayama - Universidade Federal de Mato Grosso do Sul
Valeria Aoki - Universidade de São Paulo
Evandro A. Rivitti - Universidade de São Paulo
Sebastiao A.P. Sampaio - Universidade de São Paulo
Horacio Friedman - Universidade de Brasília
Jose R. Moraes - Universidade de São Paulo
Maria E. Moraes - Universidade de São Paulo
Donald P. Eaton - University of Nevada, Reno
Argelia L. Lopez - Medical College of Wisconsin
Raymond G. Hoffman - Medical College of Wisconsin
Janet A. Fairley - Medical College of Wisconsin
George J. Giudice - Medical College of Wisconsin
Luis A. Diaz - Medical College of Wisconsin
Cooperative Group on Fogo Selvagem Research
Resource Type: Journal article
Publication Details: Journal of investigative dermatology, Vol.107(1), pp.68-75
DOI: 10.1111/1523-1747.ep12298213
PMID: 8752842
NLM abbreviation: J Invest Dermatol
ISSN: 0022-202X
eISSN: 1523-1747
Publisher: Elsevier Inc
Language: English
Date published: 07/1996
Academic Unit: Dermatology
Record Identifier: 9984296214802771

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