Journal article
An Adhesive Bioink toward Biofabrication under Wet Conditions
Small (Weinheim an der Bergstrasse, Germany), Vol.19(50), 2205078
12/2023
DOI: 10.1002/smll.202205078
PMCID: PMC10960222
PMID: 36587991
Abstract
Three-dimensional (3D) bioprinting is driving significant innovations in biomedicine over recent years. Under certain scenarios such as in intraoperative bioprinting, the bioinks used should exhibit not only cyto/biocompatibility but also adhesiveness in wet conditions. Herein, an adhesive bioink composed of gelatin methacryloyl, gelatin, methacrylated hyaluronic acid, and skin secretion of Andrias davidianus is designed. The bioink exhibits favorable cohesion to allow faithful extrusion bioprinting in wet conditions, while simultaneously showing good adhesion to a variety of surfaces of different chemical properties, possibly achieved through the diverse bonds presented in the bioink formulation. As such, this bioink is able to fabricate sophisticated planar and volumetric constructs using extrusion bioprinting, where the dexterity is further enhanced using ergonomic handheld bioprinters to realize in situ bioprinting. In vitro experiments reveal that cells maintain high viability; further in vivo studies demonstrate good integration and immediate injury sealing. The characteristics of the bioink indicate its potential widespread utility in extrusion bioprinting and will likely broaden the applications of bioprinting toward situations such as in situ dressing and minimally invasive tissue regeneration.
Details
- Title: Subtitle
- An Adhesive Bioink toward Biofabrication under Wet Conditions
- Creators
- Wanlu Li - Brigham and Women's HospitalMian Wang - Harvard UniversityShiwei WangXiaoping WangAlan AvilaXiao Kuang - Harvard UniversityXuan Mu (Author) - University of Iowa, Roy J. Carver Department of Biomedical Engineering
- Resource Type
- Journal article
- Publication Details
- Small (Weinheim an der Bergstrasse, Germany), Vol.19(50), 2205078
- DOI
- 10.1002/smll.202205078
- PMID
- 36587991
- PMCID
- PMC10960222
- NLM abbreviation
- Small
- ISSN
- 1613-6810
- eISSN
- 1613-6829
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- DOI: 10.13039/100000968, name: American Heart Association, award: 19TPA34850188; DOI: 10.13039/100008552, name: Brigham Research Institute
- Language
- English
- Electronic publication date
- 01/01/2023
- Date published
- 12/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984363947802771
Metrics
78 Record Views