An Amplitude-Integrated EEG Evaluation of Neonatal Opioid Withdrawal Syndrome

Christopher Lust; Zachary Vesoulis; John Zempel; Hongjie Gu; Stephanie Lee; Rakesh Rao; Amit M. Mathur

doi:10.1055/a-1877-9291

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An Amplitude-Integrated EEG Evaluation of Neonatal Opioid Withdrawal Syndrome

Journal article

Peer reviewed

An Amplitude-Integrated EEG Evaluation of Neonatal Opioid Withdrawal Syndrome

Christopher Lust, Zachary Vesoulis, John Zempel, Hongjie Gu, Stephanie Lee, Rakesh Rao and Amit M. Mathur

American journal of perinatology, Vol.41(S 01), pp.e290-e297

05/01/2024

DOI: 10.1055/a-1877-9291

PMCID: PMC10008470

PMID: 35709730

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10008470/pdf/nihms-1834231.pdfView

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Abstract

Objective Infants with neonatal opioid withdrawal syndrome (NOWS) have disrupted neurobehavior that requires hospitalization and treatment. This article aimed to evaluate electroencephalography (EEG) abnormalities using amplitude-integrated EEG (aEEG) in NOWS. Study Design Eighteen term born infants with NOWS were recruited prospectively for an observational pilot study. aEEG monitoring was started within 24 hours of recruitment and twice weekly through discharge. aEEG data were analyzed for background and seizures. Severity of withdrawal was monitored using the modified Finnegan scoring (MFS) system. Results Fifteen neonates had complete datasets. Thirteen (87%) had continuous aEEG background in all recordings. None had sleep-wake cyclicity (SWC) at initial recording. Brief seizures were noted in 9 of 15 (60%) infants. Lack of SWC was associated with higher MFS scores. At discharge, 8 of 15 (53%) had absent or emerging SWC. Conclusion aEEG abnormalities (absent SWC) are frequent and persist despite treatment at the time of discharge in the majority of patients with NOWS. Brief electrographic seizures are common. Neonates with persistent aEEG abnormalities at discharge warrant close follow-up.

Life Sciences & Biomedicine

Obstetrics & Gynecology

Pediatrics

Science & Technology

Details

Title: Subtitle: An Amplitude-Integrated EEG Evaluation of Neonatal Opioid Withdrawal Syndrome
Creators: Christopher Lust - Children's Minnesota
Zachary Vesoulis - Washington University in St. Louis
John Zempel - Washington University in St. Louis
Hongjie Gu - Washington University in St. Louis
Stephanie Lee - Washington University in St. Louis
Rakesh Rao - Washington University in St. Louis
Amit M. Mathur - Saint Louis University
Resource Type: Journal article
Publication Details: American journal of perinatology, Vol.41(S 01), pp.e290-e297
DOI: 10.1055/a-1877-9291
PMID: 35709730
PMCID: PMC10008470
NLM abbreviation: Am J Perinatol
ISSN: 0735-1631
eISSN: 1098-8785
Publisher: Thieme Medical Publishers
Number of pages: 8
Grant note: Barnes-Jewish Hospital Foundation NIH/NCATS UL1 TR000448 / Washington University Institute of Clinical and Translational Sciences
Language: English
Date published: 05/01/2024
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984696763802771

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