Journal article
An Analysis of Clinical Toxic Effects and Quality of Life as a Function of Radiation Dose and Volume After Lung Stereotactic Body Radiation Therapy
Advances in radiation oncology, Vol.6(6), pp.100815-100815
11/01/2021
DOI: 10.1016/j.adro.2021.100815
PMCID: PMC8655385
PMID: 34934866
Abstract
To analyze clinical toxicity and quality-of-life (QOL) outcomes among patients with stage I non-small cell lung cancer (NSCLC) after stereotactic body radiation therapy (SBRT) as a function of radiation dose and volume parameters.
In this institutional review board-approved study, 55 patients with stage I NSCLC who received SBRT (12 Gy × 4) and completed QOL forms were analyzed. Clinical symptoms and QOL outcomes were measured at baseline and at 3, 6, 12, 18, 24, and 36 months after SBRT. Clinical toxicity was graded using the
, version 4.0. Quality of life was followed using the validated Functional Assessment of Cancer Therapy-Lung-Trial Outcome Index (FACT-L-TOI) instrument. Dosimetric parameters including the mean lung radiation dose and the volume of normal lung receiving greater than 5, 10, 13, or 20 Gy (V
, V
, V
, and V
) were measured from the radiation treatment plan. Student
tests and Pearson correlation analyses were used to examine the relationships between radiation lung metrics and clinically meaningful changes in QOL and/or clinical toxic effects. The Kaplan-Meier method was used to estimate rates of local control (LC), disease-free survival (DFS), and overall survival (OS).
With a median follow-up of 24 months, the 3-year LC, DFS, and OS were 93%, 65%, and 84%, respectively, with a 5.5% rate of grade-3 toxic effects and no grade 4 or 5 toxic effects. Clinically meaningful declines in patient-reported QOL (FACT-L-TOI, lung cancer subscale, physical well-being, and/or functional well-being) posttreatment significantly correlated with increased dosimetric parameters such as V
, V
, and V
.
Although lung SBRT was associated with excellent LC and minimal clinical toxic effects for early-stage NSCLC, clinically meaningful declines in QOL were significantly correlated with increasing lung dose and volume parameters.
Details
- Title: Subtitle
- An Analysis of Clinical Toxic Effects and Quality of Life as a Function of Radiation Dose and Volume After Lung Stereotactic Body Radiation Therapy
- Creators
- Suneetha Devpura - Henry Ford Health SystemAharon M Feldman - Henry Ford Health SystemSamuel D Rusu - Henry Ford Health SystemEssa Mayyas - Henry Ford Health SystemAvielle Movsas - Henry Ford Health SystemStephen L Brown - Henry Ford Health SystemAndrew Cook - Henry Ford Health SystemMichael J Simoff - Henry Ford Health SystemZhen Sun - Henry Ford Health SystemMei Lu - Henry Ford Health SystemSean Vance - Henry Ford Health SystemMunther I Ajlouni - Henry Ford Health SystemM Salim Siddiqui - Henry Ford Health SystemIndrin J Chetty - Henry Ford Health SystemBenjamin Movsas - Henry Ford Health System
- Resource Type
- Journal article
- Publication Details
- Advances in radiation oncology, Vol.6(6), pp.100815-100815
- DOI
- 10.1016/j.adro.2021.100815
- PMID
- 34934866
- PMCID
- PMC8655385
- ISSN
- 2452-1094
- eISSN
- 2452-1094
- Language
- English
- Date published
- 11/01/2021
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984697737502771
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