An Anthropomorphic Digital Reference Object (DRO) for Simulation and Analysis of Breast DCE MRI Techniques

Leah Henze Bancroft; James Holmes; Ryan Bosca-Harasim; Jacob Johnson; Pingni Wang; Frank Korosec; Walter Block; Roberta Strigel

doi:10.3390/tomography8020081

Back

An Anthropomorphic Digital Reference Object (DRO) for Simulation and Analysis of Breast DCE MRI Techniques

Journal article

Open access

Peer reviewed

An Anthropomorphic Digital Reference Object (DRO) for Simulation and Analysis of Breast DCE MRI Techniques

Leah Henze Bancroft, James Holmes, Ryan Bosca-Harasim, Jacob Johnson, Pingni Wang, Frank Korosec, Walter Block and Roberta Strigel

Tomography (Ann Arbor), Vol.8(2), pp.1005-1023

04/02/2022

DOI: 10.3390/tomography8020081

PMCID: PMC9031444

PMID: 35448715

Files and links (1)

url

https://doi.org/10.3390/tomography8020081View

Published (Version of record) Open Access

Abstract

Advances in accelerated magnetic resonance imaging (MRI) continue to push the bounds on achievable spatial and temporal resolution while maintaining a clinically acceptable image quality. Validation tools, including numerical simulations, are needed to characterize the repeatability and reproducibility of such methods for use in quantitative imaging applications. We describe the development of a simulation framework for analyzing and optimizing accelerated MRI acquisition and reconstruction techniques used in dynamic contrast enhanced (DCE) breast imaging. The simulation framework, in the form of a digital reference object (DRO), consists of four modules that control different aspects of the simulation, including the appearance and physiological behavior of the breast tissue as well as the MRI acquisition settings, to produce simulated k-space data for a DCE breast exam. The DRO design and functionality are described along with simulation examples provided to show potential applications of the DRO. The included simulation results demonstrate the ability of the DRO to simulate a variety of effects including the creation of simulated lesions, tissue enhancement modeled by the generalized kinetic model, T1-relaxation, fat signal precession and saturation, acquisition SNR, and changes in temporal resolution.

Breast - diagnostic imaging

Computer Simulation

Contrast Media

Magnetic Resonance Imaging - methods

Reproducibility of Results

Details

Title: Subtitle: An Anthropomorphic Digital Reference Object (DRO) for Simulation and Analysis of Breast DCE MRI Techniques
Creators: Leah Henze Bancroft - University of Wisconsin–Madison
James Holmes - University of Wisconsin–Madison
Ryan Bosca-Harasim - Sanford Health
Jacob Johnson - University of Wisconsin–Madison
Pingni Wang - University of Wisconsin–Madison
Frank Korosec - University of Wisconsin–Madison
Walter Block - University of Wisconsin–Madison
Roberta Strigel - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Tomography (Ann Arbor), Vol.8(2), pp.1005-1023
DOI: 10.3390/tomography8020081
PMID: 35448715
PMCID: PMC9031444
NLM abbreviation: Tomography
ISSN: 2379-1381
eISSN: 2379-139X
Grant note: T32 GM008349 / NIGMS NIH HHS R01 CA248192 / NCI NIH HHS T32 CA009206 / NCI NIH HHS
Language: English
Date published: 04/02/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology
Record Identifier: 9984294925502771

Metrics

37 Record Views

2 Times Cited - Web of Science

See more details