Journal article
An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis
The Journal of immunology (1950), Vol.199(8), pp.2823-2833
10/15/2017
DOI: 10.4049/jimmunol.1500832
PMCID: PMC5679237
PMID: 28931602
Abstract
The role of the nucleotide-binding domain and leucine-rich repeat containing receptor NLRP10 in disease is incompletely understood. Using three mouse strains lacking the gene encoding NLRP10, only one of which had a coincidental mutation in DOCK8, we documented a role for NLRP10 as a suppressor of the cutaneous inflammatory response to
infection. There was no evidence that the enhanced local inflammation was due to enhanced inflammasome activity. NLRP10/DOCK8-deficient mice harbored lower parasite burdens at the cutaneous site of inoculation compared with wild-type controls, whereas NLRP10-deficient mice and controls had similar parasite loads, suggesting that DOCK8 promotes local growth of parasites in the skin, whereas NLRP10 does not. NLRP10-deficient mice developed vigorous adaptive immune responses, indicating that there was not a global defect in the development of Ag-specific cytokine production. Bone marrow chimeras showed that the anti-inflammatory role of NLRP10 was mediated by NLRP10 expressed in resident cells in the skin rather than by bone marrow-derived cells. These data suggest a novel role for NLRP10 in the resolution of local inflammatory responses during
infection.
Details
- Title: Subtitle
- An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis
- Creators
- Gwendolyn M Clay - Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242Diogo G Valadares - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242Joel W Graff - Veterans Affairs Medical Center, Iowa City, IA 52246Tyler K Ulland - Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242Richard E Davis - Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242; andBreanna M Scorza - Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242; andBayan Sudan Zhanbolat - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242Yani Chen - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242Fayyaz S Sutterwala - Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242; andMary E Wilson - Department of Microbiology, University of Iowa, Iowa City, IA 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.199(8), pp.2823-2833
- DOI
- 10.4049/jimmunol.1500832
- PMID
- 28931602
- PMCID
- PMC5679237
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Publisher
- United States
- Grant note
- R01 AI045540 / NIAID NIH HHS T32 AI007511 / NIAID NIH HHS R01 AI118719 / NIAID NIH HHS I01 BX001983 / BLRD VA T32 GM007337 / NIGMS NIH HHS I01 BX000536 / BLRD VA R56 AI118719 / NIAID NIH HHS R01 AI076233 / NIAID NIH HHS T32 CA009547 / NCI NIH HHS
- Language
- English
- Date published
- 10/15/2017
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984001149702771
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