Journal article
An ERP Study of Face Processing in Schizophrenia, Bipolar Disorder, and Socially Isolated Individuals from the Community
Clinical EEG and neuroscience, Vol.55(4), pp.395-405
01/31/2024
DOI: 10.1177/15500594231222979
PMCID: PMC11693041
PMID: 38298008
Abstract
People with schizophrenia (SCZ) and bipolar disorder (BD) have impairments in processing social information, including faces. The neural correlates of face processing are widely studied with the N170 ERP component. However, it is unclear whether N170 deficits reflect neural abnormalities associated with these clinical conditions or differences in social environments. The goal of this study was to determine whether N170 deficits would still be present in SCZ and BD when compared with socially isolated community members. Participants included 66 people with SCZ, 37 with BD, and 125 community members (76 "Community-Isolated"; 49 "Community-Connected"). Electroencephalography was recorded during a face processing task in which participants identified the gender of a face, the emotion of a face (angry, happy, neutral), or the number of stories in a building. We examined group differences in the N170 face effect (greater amplitudes for faces vs buildings) and the N170 emotion effect (greater amplitudes for emotional vs neutral expressions). Groups significantly differed in levels of social isolation (Community-Isolated > SCZ > BD = Community-Connected). SCZ participants had significantly reduced N170 amplitudes to faces compared with both community groups, which did not differ from each other. The BD group was intermediate and did not differ from any group. There were no significant group differences in the processing of specific emotional facial expressions. The N170 is abnormal in SCZ even when compared to socially isolated community members. Hence, the N170 seems to reflect a social processing impairment in SCZ that is separate from level of social isolation.
Details
- Title: Subtitle
- An ERP Study of Face Processing in Schizophrenia, Bipolar Disorder, and Socially Isolated Individuals from the Community
- Creators
- Lauren T Catalano - VA Greater Los Angeles Healthcare SystemJonathan K Wynn - University of California, Los AngelesNaomi I Eisenberger - University of California, Los AngelesWilliam P Horan - University of California, Los AngelesJunghee Lee - University of Alabama at BirminghamAmanda McCleery - University of IowaDavid J Miklowitz - University of California, Los AngelesEric A Reavis - University of California, Los AngelesL Felice Reddy - VA Greater Los Angeles Healthcare SystemMichael F Green - University of California, Los Angeles
- Resource Type
- Journal article
- Publication Details
- Clinical EEG and neuroscience, Vol.55(4), pp.395-405
- DOI
- 10.1177/15500594231222979
- PMID
- 38298008
- PMCID
- PMC11693041
- NLM abbreviation
- Clin EEG Neurosci
- eISSN
- 2169-5202
- Grant note
- DOI: 10.13039/100017544, name: VA Greater Los Angeles Healthcare System, award: IK2CX002202-01; DOI: 10.13039/100000002, name: National Institutes of Health, award: MH110470
- Language
- English
- Electronic publication date
- 01/31/2024
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984555558702771
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